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Can COVID-19 Increase the Risk of Herpes Zoster? A Narrative Review.
Diez-Domingo, Javier; Parikh, Raunak; Bhavsar, Amit B; Cisneros, Elisa; McCormick, Natalia; Lecrenier, Nicolas.
  • Diez-Domingo J; FISABIO-Public Health, Valencia, Spain.
  • Parikh R; GSK, Wavre, Belgium. raunak.p.parikh@gsk.com.
  • Bhavsar AB; GSK, Wavre, Belgium.
  • Cisneros E; GSK, Madrid, Spain.
  • McCormick N; GSK, Madrid, Spain.
  • Lecrenier N; GSK, Rixensart, Belgium.
Dermatol Ther (Heidelb) ; 11(4): 1119-1126, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1230303
Semantic information from SemMedBD (by NLM)
1. Disease PREDISPOSES Herpes zoster disease
Subject
Disease
Predicate
PREDISPOSES
Object
Herpes zoster disease
2. Disease PROCESS_OF Persons
Subject
Disease
Predicate
PROCESS_OF
Object
Persons
3. Cellular Immunity OCCURS_IN Persons
Subject
Cellular Immunity
Predicate
OCCURS_IN
Object
Persons
4. Herpes zoster disease COEXISTS_WITH Patient Physiological Condition
Subject
Herpes zoster disease
Predicate
COEXISTS_WITH
Object
Patient Physiological Condition
5. Disease CAUSES Herpes zoster disease
Subject
Disease
Predicate
CAUSES
Object
Herpes zoster disease
6. 2019 novel coronavirus CAUSES Disease
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
Disease
7. Disease PRECEDES Herpes zoster disease
Subject
Disease
Predicate
PRECEDES
Object
Herpes zoster disease
8. Lymphopenia PROCESS_OF Patients
Subject
Lymphopenia
Predicate
PROCESS_OF
Object
Patients
9. Herpes zoster disease PROCESS_OF Patients
Subject
Herpes zoster disease
Predicate
PROCESS_OF
Object
Patients
10. Disease PREDISPOSES Herpes zoster disease
Subject
Disease
Predicate
PREDISPOSES
Object
Herpes zoster disease
11. Disease PROCESS_OF Persons
Subject
Disease
Predicate
PROCESS_OF
Object
Persons
12. Cellular Immunity OCCURS_IN Persons
Subject
Cellular Immunity
Predicate
OCCURS_IN
Object
Persons
13. Herpes zoster disease COEXISTS_WITH Patient Physiological Condition
Subject
Herpes zoster disease
Predicate
COEXISTS_WITH
Object
Patient Physiological Condition
14. Disease CAUSES Herpes zoster disease
Subject
Disease
Predicate
CAUSES
Object
Herpes zoster disease
15. 2019 novel coronavirus CAUSES Disease
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
Disease
16. Disease PRECEDES Herpes zoster disease
Subject
Disease
Predicate
PRECEDES
Object
Herpes zoster disease
17. Lymphopenia PROCESS_OF Patients
Subject
Lymphopenia
Predicate
PROCESS_OF
Object
Patients
18. Herpes zoster disease PROCESS_OF Patients
Subject
Herpes zoster disease
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
Herpes zoster (HZ) is associated with substantial morbidity. It is caused by reactivation of the latent varicella zoster virus (VZV) following decline in cell-mediated immunity, which is commonly age-related, but also occurs in individuals with immunosuppressive diseases and/or treatment. Since coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has been associated with T cell immune dysfunction and there have been reports of HZ in COVID-19 patients, we have performed a review of available literature on whether COVID-19 could trigger HZ. We identified 27 cases of HZ following COVID-19, which most frequently occurred within 1-2 weeks of COVID-19, and the majority of cases had typical presentation. Atypical presentations of HZ were noted especially in patients with lymphopenia. It has been hypothesized that VZV reactivation occurs as a consequence of T cell dysfunction (including lymphopenia and lymphocyte exhaustion) in COVID-19 patients. Based on current evidence, which is limited to case reports and case series, it is not possible to determine whether COVID-19 increases the risk of HZ. Practitioners should be aware of the possible increased risk of HZ during the pandemic period and consider timely therapeutic and preventive measures against it.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Reviews Language: English Journal: Dermatol Ther (Heidelb) Year: 2021 Document Type: Article Affiliation country: S13555-021-00549-1

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Reviews Language: English Journal: Dermatol Ther (Heidelb) Year: 2021 Document Type: Article Affiliation country: S13555-021-00549-1