Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19.
Cell Host Microbe
; 29(7): 1052-1062, 2021 07 14.
Article
in English
| MEDLINE | ID: covidwho-1230406
ABSTRACT
COVID-19 can result in severe disease characterized by significant immunopathology that is spurred by an exuberant, yet dysregulated, innate immune response with a poor adaptive response. A limited and delayed interferon I (IFN-I) and IFN-III response results in exacerbated proinflammatory cytokine production and in extensive cellular infiltrates in the respiratory tract, resulting in lung pathology. The development of effective therapeutics for patients with severe COVID-19 depends on our understanding of the pathological elements of this unbalanced innate immune response. Here, we review the mechanisms by which SARS-CoV-2 both activates and antagonizes the IFN and inflammatory response following infection, how a dysregulated cytokine and cellular response contributes to immune-mediated pathology in COVID-19, and therapeutic strategies that target elements of the innate response.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Interferons
/
SARS-CoV-2
/
COVID-19
/
Immunity, Innate
Limits:
Animals
/
Humans
Language:
English
Journal:
Cell Host Microbe
Journal subject:
Microbiology
Year:
2021
Document Type:
Article
Affiliation country:
J.chom.2021.05.004
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