SARS-CoV-2 infection in alpha1-antitrypsin deficiency.
Respir Med
; 184: 106466, 2021 08.
Article
in English
| MEDLINE | ID: covidwho-1230754
ABSTRACT
Alpha1-antitrypsin deficiency arises due to mutations in alpha1-antitrypsin (AAT) gene and represents the most prominent genetic predisposition to chronic obstructive pulmonary disease and emphysema. Since AAT plays important immunomodulatory and tissue-protective roles and since it was suggested to protect from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, we assessed this association in United Kingdom Biobank, a community-based cohort with >500,000 participants. The most common, mild AATD genotypes were associated neither with increased SARS-CoV-2 infection rates nor with increased SARS-CoV-2 fatalities, while the numbers of severe AATD cases were too low to allow definitive conclusions.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Alpha 1-Antitrypsin Deficiency
/
Genetic Predisposition to Disease
/
COVID-19
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
English
Journal:
Respir Med
Year:
2021
Document Type:
Article
Affiliation country:
J.rmed.2021.106466
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