The Effectiveness of the Two-Dose BNT162b2 Vaccine: Analysis of Real-World Data.
Clin Infect Dis
; 74(3): 472-478, 2022 02 11.
Article
in English
| MEDLINE | ID: covidwho-1231023
ABSTRACT
BACKGROUND:
Coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccines were shown to be highly efficacious in preventing the disease in randomized controlled trials; nonetheless, evidence on the real-world effectiveness of this vaccine is limited. Study objective was to evaluate the effectiveness of BNT162b2 vaccine in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19-related hospitalization and mortality.METHODS:
This historical cohort study included members of a large health provider in Israel that were vaccinated with at least 1 dose of BNT162b2. The primary outcome was incidence rate of a SARS-CoV-2 infection confirmed with real-time polymerase chain reaction (rt-PCR), between 7 and 27 days after second dose (protection-period), as compared to days 1-7 after the first dose, where no protection by the vaccine is assumed (reference-period).RESULTS:
Data of 1 178 597 individuals vaccinated with BNT162b2 were analyzed (mean age 47.7 years [SDâ =â 18.1], 48.4% males) of whom 872 454 (74.0%) reached the protection period. Overall, 4514 infections occurred during the reference period compared to 728 during the protection period, yielding a weighted mean daily incidence of 54.8 per 100 000 (95% confidence interval [CI] 26.1-115.0 per 100 000) and 5.4 per 100 000 (95% CI 3.5-8.4 per 100 000), respectively. The vaccine effectiveness in preventing infection was 90% (95% CI 79%-95%) and 94% (95% CI 88%-97%) against COVID-19. Among immunosuppressed patients, vaccine effectiveness against infection was 71% (95% CI 37%-87%). The adjusted hazard ratios for hospitalization in those infected were 0.82 (95% CI .36-1.88), 0.45 (95% CI .23-.90), and 0.56 (95% CI .36-.89) in the age groups 16-44, 45-64. and ≥75 years, respectively.CONCLUSIONS:
The effectiveness of the BNT162b2 vaccine is comparable to the one reported in the phase III clinical trial.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
BNT162 Vaccine
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Vaccines
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
/
Young adult
Language:
English
Journal:
Clin Infect Dis
Journal subject:
Communicable Diseases
Year:
2022
Document Type:
Article
Affiliation country:
Cid
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