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Evidence for residual SARS-CoV-2 in glioblastoma tissue of a convalescent patient.
Lei, Jie; Liu, Yueping; Xie, Tianhao; Yao, Guojie; Wang, Gang; Diao, Bo; Song, Jian.
  • Lei J; Department of Neurosurgery.
  • Liu Y; Medical Laboratory Center, General Hospital of the Central Command Theater of PLA, Wuhan, PR China.
  • Xie T; Department of Neurosurgery.
  • Yao G; Department of Neurosurgery.
  • Wang G; Medical Laboratory Center, General Hospital of the Central Command Theater of PLA, Wuhan, PR China.
  • Diao B; Medical Laboratory Center, General Hospital of the Central Command Theater of PLA, Wuhan, PR China.
  • Song J; Department of Neurosurgery.
Neuroreport ; 32(9): 771-775, 2021 06 09.
Article in English | MEDLINE | ID: covidwho-1231060
ABSTRACT
Since coronavirus disease 2019 (COVID-19) swept all over the world, several studies have shown the susceptibility of a patient with cancer to COVID-19. In this case, the removed glioblastoma multiforme (GBM)-adjacent (GBM-A), GBM-peritumor and GBM-central (GBM-C) tissues from a convalescent patient of COVID-19, who also suffered from glioblastoma meanwhile, together with GBM-A and GBM tissues from a patient without COVID-19 history as negative controls, were used for RNA ISH, electron microscopy observing and immunohistochemical staining of ACE2 and the virus antigen (N protein). The results of RNA ISH, electron microscopy observing showed that SARS-CoV-2 directly infects some cells within human GBM tissues and SARS-CoV-2 in GBM-C tissue still exists even when it is cleared elsewhere. Immunohistochemical staining of ACE2 and N protein showed that the expressions of ACE2 are significantly higher in specimens, including GBM-C tissue from COVID-19 patient than other types of tissue. The unique phenomenon suggests that the surgical protection level should be upgraded even if the patient is in a convalescent period and the pharyngeal swab tests show negative results. Furthermore, more attention should be paid to confirm whether the shelter-like phenomenon happens in other malignancies due to the similar microenvironment and high expression of ACE2 in some malignancies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain Neoplasms / Glioblastoma / Coronavirus Nucleocapsid Proteins / SARS-CoV-2 / COVID-19 Type of study: Case report / Observational study / Prognostic study Limits: Adult / Humans / Male Language: English Journal: Neuroreport Journal subject: Neurology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain Neoplasms / Glioblastoma / Coronavirus Nucleocapsid Proteins / SARS-CoV-2 / COVID-19 Type of study: Case report / Observational study / Prognostic study Limits: Adult / Humans / Male Language: English Journal: Neuroreport Journal subject: Neurology Year: 2021 Document Type: Article