Your browser doesn't support javascript.
High Levels of Common Cold Coronavirus Antibodies in Convalescent Plasma Are Associated With Improved Survival in COVID-19 Patients.
Greenbaum, Uri; Klein, Kimberly; Martinez, Fernando; Song, Juhee; Thall, Peter F; Ramdial, Jeremy L; Knape, Cristina; Aung, Fleur M; Scroggins, Jamie; Knopfelmacher, Adriana; Mulanovich, Victor; Borjan, Jovan; Adachi, Javier; Muthu, Mayoora; Leung, Cerena; Medina, Mayrin Correa; Champlin, Richard; Olson, Amanda; Alousi, Amin; Rezvani, Katayoun; Shpall, Elizabeth J.
  • Greenbaum U; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
  • Klein K; Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
  • Martinez F; Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
  • Song J; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
  • Thall PF; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
  • Ramdial JL; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
  • Knape C; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
  • Aung FM; Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
  • Scroggins J; Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
  • Knopfelmacher A; Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
  • Mulanovich V; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
  • Borjan J; Pharmacy Clinical Programs, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
  • Adachi J; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
  • Muthu M; Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
  • Leung C; Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
  • Medina MC; Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
  • Champlin R; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
  • Olson A; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
  • Alousi A; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
  • Rezvani K; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
  • Shpall EJ; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Front Immunol ; 12: 675679, 2021.
Article in English | MEDLINE | ID: covidwho-1231340
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
ABSTRACT

Background:

COVID-19 Convalescent plasma (CCP) is safe and effective, particularly if given at an early stage of the disease. Our study aimed to identify an association between survival and specific antibodies found in CCP. Patients and

Methods:

Patients ≥18 years of age who were hospitalized with moderate to severe COVID-19 infection and received CCP at the MD Anderson Cancer Center between 4/30/2020 and 8/20/2020 were included in the study. We quantified the levels of anti-SARS-CoV-2 antibodies, as well as antibodies against antigens of other coronavirus strains, in the CCP units and compared antibody levels with patient outcomes. For each antibody, a Bayesian exponential survival time regression model including prognostic variables was fit, and the posterior probability of a beneficial effect (PBE) of higher antibody level on survival time was computed.

Results:

CCP was administered to 44 cancer patients. The median age was 60 years (range 37-84) and 19 (43%) were female. Twelve patients (27%) died of COVID-19-related complications. Higher levels of two non-SARS-CoV-2-specific antibodies, anti-HCoV-OC43 spike IgG and anti-HCoV-HKU1 spike IgG, had PBE = 1.00, and 4 SARS-CoV-2-specific antibodies had PBEs between 0.90 and 0.95. Other factors associated with better survival were shorter time to CCP administration, younger age, and female sex.

Conclusions:

Common cold coronavirus spike IgG antibodies anti-HCoV-OC43 and anti-HCoV-HKU1 may target a common domain for SARS-CoV-2 and other coronaviruses. They provide a promising therapeutic target for monoclonal antibody production.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Convalescence / Common Cold / Coronavirus OC43, Human / Spike Glycoprotein, Coronavirus / Betacoronavirus / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.675679

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Convalescence / Common Cold / Coronavirus OC43, Human / Spike Glycoprotein, Coronavirus / Betacoronavirus / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.675679