Your browser doesn't support javascript.
Prevalence of Venous Thromboembolism in Critically Ill Patients With Coronavirus Disease 2019: A Meta-Analysis.
Wu, Changgang; Liu, Yunlong; Cai, Xiangjing; Zhang, Wenming; Li, Yongjie; Fu, Chunsheng.
  • Wu C; Department of Respiration, Liaocheng Infectious Disease Hospital, Liaochen, China.
  • Liu Y; Department of Infectious Diseases, Liaocheng Infectious Disease Hospital, Liaocheng, China.
  • Cai X; Department of Respiration, Liaocheng Infectious Disease Hospital, Liaochen, China.
  • Zhang W; Department of Critical Care Medicine, Liaocheng Infectious Disease Hospital, Liaocheng, China.
  • Li Y; Department of Respiration, Liaocheng Infectious Disease Hospital, Liaochen, China.
  • Fu C; Department of Infectious Diseases, Liaocheng Infectious Disease Hospital, Liaocheng, China.
Front Med (Lausanne) ; 8: 603558, 2021.
Article in English | MEDLINE | ID: covidwho-1231346
ABSTRACT

Background:

Accumulating evidence suggests that coronavirus disease 2019 (COVID-19) is associated with hypercoagulative status, particularly for critically ill patients in the intensive care unit. However, the prevalence of venous thromboembolism (VTE) in these patients under routine prophylactic anticoagulation remains unknown. A meta-analysis was performed to evaluate the prevalence of VTE in these patients by pooling the results of these observational studies.

Methods:

Observational studies that reported the prevalence of VTE in critically ill patients with COVID-19 were identified by searching the PubMed and Embase databases. A random-effect model was used to pool the results by incorporating the potential heterogeneity.

Results:

A total of 19 studies with 1,599 patients were included. The pooled results revealed that the prevalence of VTE, deep venous thrombosis (DVT), and pulmonary embolism (PE) in critically ill patients with COVID-19 was 28.4% [95% confidence interval (CI) 20.0-36.8%], 25.6% (95% CI 17.8-33.4%), and 16.4% (95% CI 10.1-22.7%), respectively. Limited to studies, in which all patients received routine prophylactic anticoagulation, and the prevalence for VTE, DVT, and PE was 30.1% (95% CI 19.4-40.8%), 27.2% (95% CI 16.5-37.9%), and 18.3% (95% CI 9.8%-26.7%), respectively. The prevalence of DVT was higher in studies with routine screening for all patients, when compared to studies with screening only in clinically suspected patients (47.5% vs. 15.1%, P < 0.001).

Conclusion:

Critically ill patients with COVID-19 have a high prevalence of VTE, despite the use of present routine prophylactic anticoagulation.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews Language: English Journal: Front Med (Lausanne) Year: 2021 Document Type: Article Affiliation country: Fmed.2021.603558

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews Language: English Journal: Front Med (Lausanne) Year: 2021 Document Type: Article Affiliation country: Fmed.2021.603558