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Extracellular Vesicles and Asthma-More Than Just a Co-Existence.
Alashkar Alhamwe, Bilal; Potaczek, Daniel P; Miethe, Sarah; Alhamdan, Fahd; Hintz, Lukas; Magomedov, Arslan; Garn, Holger.
  • Alashkar Alhamwe B; Institute of Tumor Immunology, Clinic for Hematology, Oncology and Immunology, Center for Tumor Biology and Immunology, Philipps University Marburg, 35043 Marburg, Germany.
  • Potaczek DP; College of Pharmacy, International University for Science and Technology (IUST), Daraa 15, Syria.
  • Miethe S; Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, Philipps University Marburg, 35043 Marburg, Germany.
  • Alhamdan F; Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, Philipps University Marburg, 35043 Marburg, Germany.
  • Hintz L; Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, Philipps University Marburg, 35043 Marburg, Germany.
  • Magomedov A; Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, Philipps University Marburg, 35043 Marburg, Germany.
  • Garn H; Institute of Tumor Immunology, Clinic for Hematology, Oncology and Immunology, Center for Tumor Biology and Immunology, Philipps University Marburg, 35043 Marburg, Germany.
Int J Mol Sci ; 22(9)2021 May 07.
Article in English | MEDLINE | ID: covidwho-1231495
ABSTRACT
Extracellular vesicles (EVs) are membranous structures, which are secreted by almost every cell type analyzed so far. In addition to their importance for cell-cell communication under physiological conditions, EVs are also released during pathogenesis and mechanistically contribute to this process. Here we summarize their functional relevance in asthma, one of the most common chronic non-communicable diseases. Asthma is a complex persistent inflammatory disorder of the airways characterized by reversible airflow obstruction and, from a long-term perspective, airway remodeling. Overall, mechanistic studies summarized here indicate the importance of different subtypes of EVs and their variable cargoes in the functioning of the pathways underlying asthma, and show some interesting potential for the development of future therapeutic interventions. Association studies in turn demonstrate a good diagnostic potential of EVs in asthma.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Extracellular Vesicles Type of study: Prognostic study Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms22094984

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Extracellular Vesicles Type of study: Prognostic study Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms22094984