Your browser doesn't support javascript.
Nucleocapsid and Spike Proteins of SARS-CoV-2 Drive Neutrophil Extracellular Trap Formation.
Youn, Young-Jin; Lee, Yu-Bin; Kim, Sun-Hwa; Jin, Hee Kyung; Bae, Jae-Sung; Hong, Chang-Won.
  • Youn YJ; Department of Physiology, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
  • Lee YB; Department of Physiology, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
  • Kim SH; Department of Physiology, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
  • Jin HK; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu 41944, Korea.
  • Bae JS; KNU Alzheimer's Disease Research Institute, School of Medicine, Kyungpook National University, Daege 41566, Korea.
  • Hong CW; Department of Physiology, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
Immune Netw ; 21(2): e16, 2021 Apr.
Article in English | MEDLINE | ID: covidwho-1231554
ABSTRACT
Patients with severe coronavirus disease 2019 (COVID-19) demonstrate dysregulated immune responses including exacerbated neutrophil functions. Massive neutrophil infiltrations accompanying neutrophil extracellular trap (NET) formations are also observed in patients with severe COVID-19. However, the mechanism underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced NET formation has not yet been elucidated. Here we show that 2 viral proteins encoded by SARS-CoV-2, the nucleocapsid protein and the whole spike protein, induce NET formation from neutrophils. NET formation was ROS-independent and was completely inhibited by the spleen tyrosine kinase inhibition. The inhibition of p38 MAPK, protein kinase C, and JNK signaling pathways also inhibited viral protein-induced NET formation. Our findings demonstrate one method by which SARS-CoV-2 evades innate immunity and provide a potential target for therapeutics to treat patients with severe COVID-19.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Immune Netw Year: 2021 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Immune Netw Year: 2021 Document Type: Article