A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS
Wellcome Open Research
; 6:38, 2021.
Article
in English
| MEDLINE | ID: covidwho-1231592
ABSTRACT
Background:
Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with mortality caused by coronavirus disease 2019 (COVID-19). Neutrophils play a key role in the lung injury characteristic of non-COVID-19 ARDS and there is also accumulating evidence of neutrophil mediated lung injury in patients who succumb to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Methods:
We undertook a functional proteomic and metabolomic survey of circulating neutrophil populations, comparing patients with COVID-19 ARDS and non-COVID-19 ARDS to understand the molecular basis of neutrophil dysregulation.
Full text:
Available
Collection:
Databases of international organizations
Database:
MEDLINE
Language:
English
Journal:
Wellcome Open Research
Year:
2021
Document Type:
Article
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