Excess Soluble fms-like Tyrosine Kinase 1 Correlates With Endothelial Dysfunction and Organ Failure in Critically Ill Coronavirus Disease 2019 Patients.

Dupont, Vincent; Kanagaratnam, Lukshe; Goury, Antoine; Poitevin, Gaël; Bard, Mathieu; Julien, Gauthier; Bonnivard, Michel; Champenois, Vanessa; Noel, Violaine; Mourvillier, Bruno; Nguyen, Philippe

Dupont, Vincent; Kanagaratnam, Lukshe; Goury, Antoine; Poitevin, Gaël; Bard, Mathieu; Julien, Gauthier; Bonnivard, Michel; Champenois, Vanessa; Noel, Violaine; Mourvillier, Bruno; Nguyen, Philippe.

Dupont V; Medical Intensive Care Unit, University Hospital of Reims, Reims, France.
Kanagaratnam L; EA-3801, SFT CAP-Santé, University of Reims Champagne Ardenne, France.
Goury A; Clinical Research Unit, University Hospital of Reims, Reims, France.
Poitevin G; Medical Intensive Care Unit, University Hospital of Reims, Reims, France.
Bard M; EA-3801, SFT CAP-Santé, University of Reims Champagne Ardenne, France.
Julien G; Medical Intensive Care Unit, University Hospital of Reims, Reims, France.
Bonnivard M; Medical Intensive Care Unit, University Hospital of Reims, Reims, France.
Champenois V; Medical Intensive Care Unit, University Hospital of Reims, Reims, France.
Noel V; Medical Intensive Care Unit, University Hospital of Reims, Reims, France.
Mourvillier B; Department of Internal Medicine, Clinical Immunology and Infectious Diseases, University Hospital of Reims, Reims, France.
Nguyen P; Medical Intensive Care Unit, University Hospital of Reims, Reims, France.

Clin Infect Dis ; 72(10): 1834-1837, 2021 05 18.

Article in English | MEDLINE | ID: covidwho-1232179

ABSTRACT

ABSTRACT

Excess soluble fms-like tyrosine kinase 1 (sFlt-1), a soluble inhibitor of vascular endothelial growth factor pathway, has been demonstrated to promote endothelial dysfunction. Here, we demonstrate that sFlt-1 plasma levels correlate with respiratory symptom severity, expression of endothelial dysfunction biomarker, and incidence of organ failure in coronavirus disease 2019 patients. Clinical Trials Registration NCT04394195.

Subject(s)

COVID-19; Vascular Endothelial Growth Factor Receptor-1; Critical Illness; Humans; SARS-CoV-2; Vascular Endothelial Growth Factor A

Keywords

COVID-19; critical care; endothelial dysfunction; sFlt-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vascular Endothelial Growth Factor Receptor-1 / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid

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