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ACE2 polymorphism and susceptibility for SARS-CoV-2 infection and severity of COVID-19.
Möhlendick, Birte; Schönfelder, Kristina; Breuckmann, Katharina; Elsner, Carina; Babel, Nina; Balfanz, Paul; Dahl, Edgar; Dreher, Michael; Fistera, David; Herbstreit, Frank; Hölzer, Bodo; Koch, Michael; Kohnle, Matthias; Marx, Nikolaus; Risse, Joachim; Schmidt, Karsten; Skrzypczyk, Sarah; Sutharsan, Sivagurunathan; Taube, Christian; Westhoff, Timm H; Jöckel, Karl-Heinz; Dittmer, Ulf; Siffert, Winfried; Kribben, Andreas.
  • Möhlendick B; Institute of Pharmacogenetics.
  • Schönfelder K; Department of Nephrology.
  • Breuckmann K; Institute of Diagnostic and Interventional Radiology and Neuroradiology.
  • Elsner C; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen.
  • Babel N; Center for Translational Medicine, Ruhr University Bochum, Herne.
  • Balfanz P; Department of Cardiology, Angiology and Intensive Care Medicine, University Hospital Aachen.
  • Dahl E; RWTH Centralized Biomaterial Bank (RWTH cBMB), Medical Faculty.
  • Dreher M; Department of Pneumology and Intensive Care Medicine, University Hospital Aachen, RWTH Aachen University, Aachen.
  • Fistera D; Center of Emergency Medicine.
  • Herbstreit F; Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University of Duisburg-Essen, Essen.
  • Hölzer B; Department of Nephrology, Ruhr University Bochum, Herne.
  • Koch M; Center of Nephrology Mettmann, Mettmann.
  • Kohnle M; Center of Nephrology Mettmann, Mettmann.
  • Marx N; Department of Cardiology, Angiology and Intensive Care Medicine, University Hospital Aachen.
  • Risse J; Center of Emergency Medicine.
  • Schmidt K; Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University of Duisburg-Essen, Essen.
  • Skrzypczyk S; Center for Translational Medicine, Ruhr University Bochum, Herne.
  • Sutharsan S; Department of Pulmonary Medicine, Ruhrlandklinik, University Hospital Essen.
  • Taube C; Department of Pulmonary Medicine, Ruhrlandklinik, University Hospital Essen.
  • Westhoff TH; Department of Nephrology, Ruhr University Bochum, Herne.
  • Jöckel KH; Institute of Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany.
  • Dittmer U; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen.
  • Siffert W; Institute of Pharmacogenetics.
  • Kribben A; Department of Nephrology.
Pharmacogenet Genomics ; 31(8): 165-171, 2021 10 01.
Article in English | MEDLINE | ID: covidwho-1232235
ABSTRACT

OBJECTIVES:

The RNA virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19). Cell entry is mediated by the human angiotensin-converting enzyme II (ACE2). ACE2 and its close homolog angiotensin-converting enzyme I (ACE) are currently discussed candidate genes, in which single-nucleotide polymorphisms (SNPs) could alter binding or entry of SARS-CoV-2 and enhance tissue damage in the lung or other organs. This could increase the susceptibility for SARS-CoV-2 infection and the severity of COVID-19. PATIENTS AND

METHODS:

We performed genotyping of SNPs in the genes ACE2 and ACE in 297 SARS-CoV-2-positive and 253 SARS-CoV-2-negative tested patients. We analyzed the association of the SNPs with susceptibility for SARS-CoV-2 infection and the severity of COVID-19.

RESULTS:

SARS-CoV-2-positive and SARS-CoV-2-negative patients did not differ regarding demographics and clinical characteristics. For ACE2 rs2285666, the GG genotype or G-allele was significantly associated with an almost two-fold increased SARS-CoV-2 infection risk and a three-fold increased risk to develop serious disease or COVID-19 fatality. In contrast, the ACE polymorphism was not related to infection risk or severity of disease. In a multivariable analysis, the ACE2 rs2285666 G-allele remained as an independent risk factor for serious disease besides the known risk factors male gender and cardiovascular disease.

CONCLUSIONS:

In summary, our report appears to be the first showing that a common ACE2 polymorphism impacts the risk for SARS-CoV-2 infection and the course of COVID-19 independently from previously described risk factors.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Genetic Predisposition to Disease / Angiotensin-Converting Enzyme 2 / COVID-19 Type of study: Prognostic study Topics: Variants Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Pharmacogenet Genomics Journal subject: Pharmacology / Genetics, Medical Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Genetic Predisposition to Disease / Angiotensin-Converting Enzyme 2 / COVID-19 Type of study: Prognostic study Topics: Variants Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Pharmacogenet Genomics Journal subject: Pharmacology / Genetics, Medical Year: 2021 Document Type: Article