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Induction of Humoral and Cellular Immunity by Intradermal Delivery of SARS-CoV-2 Nucleocapsid Protein Using Dissolvable Microneedles.
Kuwentrai, Chaiyaporn; Yu, Jinming; Zhang, Bao-Zhong; Hu, Ye-Fan; Dou, Ying; Gong, Hua-Rui; Huang, Jian-Dong; Xu, Chenjie.
  • Kuwentrai C; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 3/F, Laboratory Block, 21 Sassoon Road, Hong Kong SAR, China.
  • Yu J; Department of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, China.
  • Zhang BZ; CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
  • Hu YF; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 3/F, Laboratory Block, 21 Sassoon Road, Hong Kong SAR, China.
  • Dou Y; Department of Medicine, University of Hong Kong, 4/F Professional Block, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China.
  • Gong HR; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 3/F, Laboratory Block, 21 Sassoon Road, Hong Kong SAR, China.
  • Huang JD; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 3/F, Laboratory Block, 21 Sassoon Road, Hong Kong SAR, China.
  • Xu C; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 3/F, Laboratory Block, 21 Sassoon Road, Hong Kong SAR, China.
J Immunol Res ; 2021: 5531220, 2021.
Article in English | MEDLINE | ID: covidwho-1232374
ABSTRACT
The nucleocapsid protein (NP) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains immunogenic epitopes that can induce cytotoxic T lymphocyte (CTL) against viral infection. This makes the nucleocapsid protein a suitable candidate for developing a vaccine against SARS-CoV-2 infection. This article reports the intradermal delivery of NP antigen using dissolvable microneedle skin patches that could induce both significant B cell and T cell responses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: T-Lymphocytes, Cytotoxic / Coronavirus Nucleocapsid Proteins / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Antibodies, Viral Topics: Vaccines Limits: Animals Language: English Journal: J Immunol Res Year: 2021 Document Type: Article Affiliation country: 2021

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Full text: Available Collection: International databases Database: MEDLINE Main subject: T-Lymphocytes, Cytotoxic / Coronavirus Nucleocapsid Proteins / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Antibodies, Viral Topics: Vaccines Limits: Animals Language: English Journal: J Immunol Res Year: 2021 Document Type: Article Affiliation country: 2021