Your browser doesn't support javascript.
Contribution of rapid lateral flow assays from capillary blood specimens to the diagnosis of COVID-19 in symptomatic healthcare workers: a pilot study in a university hospital, Paris, France.
Charpentier, Charlotte; Pellissier, Gérard; Ichou, Houria; Ferré, Valentine Marie; Larfi, Isabelle; Phung, Bao-Chau; Vallois, Dorothée; LeGac, Sylvie; Aubier, Michel; Descamps, Diane; Fidouh-Houhou, Nadhira; Bouvet, Elisabeth.
  • Charpentier C; Service de Virologie, Université de Paris, INSERM, IAME, UMR 1137, AP-HP, Hôpital Bichat-Claude Bernard, Paris, France. Electronic address: charlotte.charpentier@aphp.fr.
  • Pellissier G; Groupe d'Étude sur le Risque d'Exposition des Soignants aux agents infectieux (GERES), UFR de Médecine Bichat, Paris, France.
  • Ichou H; Service de Virologie, Université de Paris, INSERM, IAME, UMR 1137, AP-HP, Hôpital Bichat-Claude Bernard, Paris, France.
  • Ferré VM; Service de Virologie, Université de Paris, INSERM, IAME, UMR 1137, AP-HP, Hôpital Bichat-Claude Bernard, Paris, France.
  • Larfi I; Inserm U1152, Université de Paris, Site Bichat, Paris, France.
  • Phung BC; Service de Maladies Infectieuses et Tropicales, Hôpital Bichat-Claude Bernard, Paris, France.
  • Vallois D; Service de Maladies Infectieuses et Tropicales, Hôpital Bichat-Claude Bernard, Paris, France.
  • LeGac S; Service de Maladies Infectieuses et Tropicales, Hôpital Bichat-Claude Bernard, Paris, France; COREVIH Ile-de-France Nord, Paris, France.
  • Aubier M; Inserm U1152, Université de Paris, Site Bichat, Paris, France.
  • Descamps D; Service de Virologie, Université de Paris, INSERM, IAME, UMR 1137, AP-HP, Hôpital Bichat-Claude Bernard, Paris, France.
  • Fidouh-Houhou N; Service de Virologie, Université de Paris, INSERM, IAME, UMR 1137, AP-HP, Hôpital Bichat-Claude Bernard, Paris, France.
  • Bouvet E; Service de Maladies Infectieuses et Tropicales, Hôpital Bichat-Claude Bernard, Paris, France; COREVIH Ile-de-France Nord, Paris, France.
Diagn Microbiol Infect Dis ; 101(2): 115430, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-1233407
ABSTRACT

BACKGROUND:

This study aimed to assess, by rapid tests, the immune status against COVID-19 among Healthcare Workers (HCW) with history of symptoms, and for whom SARS-CoV-2 detection was either not documented or negative.

METHODS:

Whole blood by finger prick and serum samples were taken from HCW for use with 2 rapid lateral flow tests and an automated immunoassay.

RESULTS:

Seventy-two HCWs were included, median duration between symptoms onset and serology sampling was 68 days. Anti-SARS-CoV-2 antibodies were detected by rapid test in 11 HCW (15.3%) and confirmed in the 10 with available serum by the automated immunoassay. The frequency of ageusia or anosmia was higher in participants with SARS-CoV-2 antibodies (P = 0.0006 and P = 0.029, respectively).

CONCLUSIONS:

This study, among symptomatic HCW during the first wave in France, showed that 15% had IgG anti-SARS-CoV-2, a higher seroprevalence than in the general population. Rapid lateral flow tests were highly concordant with automated immunoassay.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Health Personnel / Point-of-Care Testing / COVID-19 Serological Testing / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Diagn Microbiol Infect Dis Year: 2021 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Health Personnel / Point-of-Care Testing / COVID-19 Serological Testing / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Diagn Microbiol Infect Dis Year: 2021 Document Type: Article