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SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition.
Altmann, Daniel M; Reynolds, Catherine J; Boyton, Rosemary J.
  • Altmann DM; Department of Immunology and Inflammation, Imperial College London, London, UK.
  • Reynolds CJ; Department of Infectious Disease, Imperial College London, London, UK.
  • Boyton RJ; Department of Infectious Disease, Imperial College London, London, UK.
Cell Rep Med ; 2(5): 100286, 2021 05 18.
Article in English | MEDLINE | ID: covidwho-1233636
ABSTRACT
COVID-19 variants of concern, including B.1.1.7, B.1.351, and P.1, encompass mutations facilitating immune evasion. Neutralizing antibody recognition and function may be variably impaired. We considered the impact of mutations on T cell responses. Mutations could be neutral or result in either loss or gain of predicted epitopes depending on HLA type.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: T-Lymphocytes / Antibodies, Neutralizing / SARS-CoV-2 Type of study: Experimental Studies / Prognostic study Topics: Variants Limits: Humans Language: English Journal: Cell Rep Med Year: 2021 Document Type: Article Affiliation country: J.xcrm.2021.100286

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Full text: Available Collection: International databases Database: MEDLINE Main subject: T-Lymphocytes / Antibodies, Neutralizing / SARS-CoV-2 Type of study: Experimental Studies / Prognostic study Topics: Variants Limits: Humans Language: English Journal: Cell Rep Med Year: 2021 Document Type: Article Affiliation country: J.xcrm.2021.100286