Your browser doesn't support javascript.
Diffuse trophoblast damage is the hallmark of SARS-CoV-2-associated fetal demise.
Garrido-Pontnou, Marta; Navarro, Alexandra; Camacho, Jessica; Crispi, Fàtima; Alguacil-Guillén, Marina; Moreno-Baró, Anna; Hernandez-Losa, Javier; Sesé, Marta; Ramón Y Cajal, Santiago; Garcia Ruíz, Itziar; Serrano, Berta; Garcia-Aguilar, Paula; Suy, Anna; Ferreres, Joan Carles; Nadal, Alfons.
  • Garrido-Pontnou M; Pathology Department, Hospital Universitari Vall d'Hebron, Department of Morphological Sciences, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Navarro A; Pathology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
  • Camacho J; Pathology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
  • Crispi F; Department of Maternal-Fetal Medicine, BCNatal, Barcelona Center for Maternal-Fetal and Neonatal Medicine, Hospital Clínic and Hospital Sant Joan de Déu, IDIBAPS, Universitat de Barcelona, Barcelona, Spain.
  • Alguacil-Guillén M; Microbiology Department, Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Spain.
  • Moreno-Baró A; Pathology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
  • Hernandez-Losa J; Obstetrics Department, Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Spain.
  • Sesé M; Pathology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
  • Ramón Y Cajal S; Pathology Department, Hospital Universitari Vall d'Hebron. Translational Molecular Pathology, Vall d'Hebron Institute of Research (VHIR)., Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Garcia Ruíz I; Pathology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
  • Serrano B; Pathology Department, Hospital Universitari Vall d'Hebron. Translational Molecular Pathology, Vall d'Hebron Institute of Research (VHIR)., Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Garcia-Aguilar P; Pathology Department, Hospital Universitari Vall d'Hebron, Department of Morphological Sciences, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Suy A; Obstetrics Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
  • Ferreres JC; Obstetrics Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
  • Nadal A; Obstetrics Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Mod Pathol ; 34(9): 1704-1709, 2021 09.
Article in English | MEDLINE | ID: covidwho-1233700
ABSTRACT
Placental pathology in SARS-CoV-2-infected pregnancies seems rather unspecific. However, the identification of the placental lesions due to SARS-CoV-2 infection would be a significant advance in order to improve the management of these pregnancies and to identify the mechanisms involved in a possible vertical transmission. The pathological findings in placentas delivered from 198 SARS-CoV-2-positive pregnant women were investigated for the presence of lesions associated with placental SARS-CoV-2 infection. SARS-CoV-2 infection was investigated in placental tissues through immunohistochemistry, and positive cases were further confirmed by in situ hybridization. SARS-CoV-2 infection was also investigated by RT-PCR in 33 cases, including all the immunohistochemically positive cases. Nine cases were SARS-CoV-2-positive by immunohistochemistry, in situ hybridization, and RT-PCR. These placentas showed lesions characterized by villous trophoblast necrosis with intervillous space collapse and variable amounts of mixed intervillous inflammatory infiltrate and perivillous fibrinoid deposition. Such lesions ranged from focal to massively widespread in five cases, resulting in intrauterine fetal death. Two of the stillborn fetuses showed some evidence of SARS-CoV-2 positivity. The remaining 189 placentas did not show similar lesions. The strong association between trophoblastic damage and placenta SARS-CoV-2 infection suggests that this lesion is a specific marker of SARS-CoV-2 infection in placenta. Diffuse trophoblastic damage, massively affecting chorionic villous tissue, can result in fetal death associated with COVID-19 disease.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Trophoblasts / Fetal Death / COVID-19 Topics: Long Covid Limits: Adult / Female / Humans / Pregnancy Language: English Journal: Mod Pathol Journal subject: Pathology Year: 2021 Document Type: Article Affiliation country: S41379-021-00827-5

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Trophoblasts / Fetal Death / COVID-19 Topics: Long Covid Limits: Adult / Female / Humans / Pregnancy Language: English Journal: Mod Pathol Journal subject: Pathology Year: 2021 Document Type: Article Affiliation country: S41379-021-00827-5