Peroxisomes exhibit compromised structure and matrix protein content in SARS-CoV-2-infected cells.
Mol Biol Cell
; 32(14): 1273-1282, 2021 07 01.
Article
in English
| MEDLINE | ID: covidwho-1233836
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that has triggered global health and economic crises. Here we report the effects of SARS-CoV-2 infection on peroxisomes of human cell lines Huh-7 and SK-N-SH. Peroxisomes undergo dramatic changes in morphology in SARS-CoV-2-infected cells. Rearrangement of peroxisomal membranes is followed by redistribution of peroxisomal matrix proteins to the cytosol, resulting in a dramatic decrease in the number of mature peroxisomes. The SARS-CoV-2 ORF14 protein was shown to interact physically with human PEX14, a peroxisomal membrane protein required for matrix protein import and peroxisome biogenesis. Given the important roles of peroxisomes in innate immunity, SARS-CoV-2 may directly target peroxisomes, resulting in loss of peroxisome structural integrity, matrix protein content and ability to function in antiviral signaling.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Peroxisomes
Limits:
Animals
/
Humans
Language:
English
Journal:
Mol Biol Cell
Journal subject:
Molecular Biology
Year:
2021
Document Type:
Article
Affiliation country:
Mbc.E21-02-0074
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