Your browser doesn't support javascript.
COVID-19 in hospitalized lung and non-lung solid organ transplant recipients: A comparative analysis from a multicenter study.
Heldman, Madeleine R; Kates, Olivia S; Safa, Kassem; Kotton, Camille N; Georgia, Sarah J; Steinbrink, Julie M; Alexander, Barbara D; Hemmersbach-Miller, Marion; Blumberg, Emily A; Crespo, Maria M; Multani, Ashrit; Lewis, Angelica V; Eugene Beaird, Omer; Haydel, Brandy; La Hoz, Ricardo M; Moni, Lisset; Condor, Yesabeli; Flores, Sandra; Munoz, Carlos G; Guitierrez, Juan; Diaz, Esther I; Diaz, Daniela; Vianna, Rodrigo; Guerra, Giselle; Loebe, Matthias; Rakita, Robert M; Malinis, Maricar; Azar, Marwan M; Hemmige, Vagish; McCort, Margaret E; Chaudhry, Zohra S; Singh, Pooja; Hughes, Kailey; Velioglu, Arzu; Yabu, Julie M; Morillis, Jose A; Mehta, Sapna A; Tanna, Sajal D; Ison, Michael G; Tomic, Rade; Candace Derenge, Ariella; van Duin, David; Maximin, Adrienne; Gilbert, Carlene; Goldman, Jason D; Sehgal, Sameep; Weisshaar, Dana; Girgis, Reda E; Nelson, Joanna; Lease, Erika D.
  • Heldman MR; Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington.
  • Kates OS; Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington.
  • Safa K; Transplant Center and Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts.
  • Kotton CN; Division of Transplant Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts.
  • Georgia SJ; Transplant Center and Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts.
  • Steinbrink JM; Division of Infectious Diseases, Department of Medicine, Duke University, Durham, North Carolina.
  • Alexander BD; Division of Infectious Diseases, Department of Medicine, Duke University, Durham, North Carolina.
  • Hemmersbach-Miller M; Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas.
  • Blumberg EA; Department of Medicine, Division of Infectious Diseases, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
  • Crespo MM; Department of Medicine, Division of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
  • Multani A; Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.
  • Lewis AV; Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.
  • Eugene Beaird O; Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.
  • Haydel B; Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York City, New York.
  • La Hoz RM; Division of Infectious Diseases and Geographic Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Moni L; Miami Transplant Institute, University of Miami/Jackson Memorial Hospital, Miami, Florida.
  • Condor Y; Miami Transplant Institute, University of Miami/Jackson Memorial Hospital, Miami, Florida.
  • Flores S; Miami Transplant Institute, University of Miami/Jackson Memorial Hospital, Miami, Florida.
  • Munoz CG; Miami Transplant Institute, University of Miami/Jackson Memorial Hospital, Miami, Florida.
  • Guitierrez J; Miami Transplant Institute, University of Miami/Jackson Memorial Hospital, Miami, Florida.
  • Diaz EI; Miami Transplant Institute, University of Miami/Jackson Memorial Hospital, Miami, Florida.
  • Diaz D; Miami Transplant Institute, University of Miami/Jackson Memorial Hospital, Miami, Florida.
  • Vianna R; Miami Transplant Institute, University of Miami/Jackson Memorial Hospital, Miami, Florida.
  • Guerra G; Miami Transplant Institute, University of Miami/Jackson Memorial Hospital, Miami, Florida.
  • Loebe M; Miami Transplant Institute, University of Miami/Jackson Memorial Hospital, Miami, Florida.
  • Rakita RM; Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington.
  • Malinis M; Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
  • Azar MM; Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
  • Hemmige V; Division of Infectious Disease, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York.
  • McCort ME; Division of Infectious Disease, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York.
  • Chaudhry ZS; Transplantation Infectious Diseases and Immunotherapy, Henry Ford Health System, Detroit, Michigan.
  • Singh P; Division of Nephrology, University of New Mexico School of Medicine, Albuquerque, New Mexico.
  • Hughes K; Transplant Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania.
  • Velioglu A; School of Medicine, Division of Nephrology, Department of Internal Medicine, Marmara University, Istanbul, Turkey.
  • Yabu JM; Division of Nephrology, Department of Medicine, University of California at Los Angeles, Los Angeles, California.
  • Morillis JA; Department of Infectious Diseases, Cleveland Clinic, Cleveland, Ohio.
  • Mehta SA; NYU Langone Transplant Institute, New York University, New York City, New York.
  • Tanna SD; Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Ison MG; Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Tomic R; Division of Pulmonology and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Candace Derenge A; Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania.
  • van Duin D; Division of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina.
  • Maximin A; Nazih Zuhdi Transplant Institute, INTEGRIS Baptist Medical Center, Oklahoma City, Oklahoma.
  • Gilbert C; Banner-University Medicine Transplant Institute, Banner Health, Phoenix, Arizona.
  • Goldman JD; Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington.
  • Sehgal S; Division of Infectious Diseases, Swedish Medical Center, Seattle, Washington.
  • Weisshaar D; Department of Thoracic Medicine and Surgery, Temple University, Philadelphia, Pennsylvania.
  • Girgis RE; Heart Transplant Department, Kaiser Permanente, Santa Clara, California.
  • Nelson J; Richard DeVos Lung Transplant Program, Spectrum Health, Grand Rapids, Michigan.
  • Lease ED; Division of Infectious Diseases, Stanford University, Palo Alto, California.
Am J Transplant ; 21(8): 2774-2784, 2021 08.
Article in English | MEDLINE | ID: covidwho-1234215
ABSTRACT
Lung transplant recipients (LTR) with coronavirus disease 2019 (COVID-19) may have higher mortality than non-lung solid organ transplant recipients (SOTR), but direct comparisons are limited. Risk factors for mortality specifically in LTR have not been explored. We performed a multicenter cohort study of adult SOTR with COVID-19 to compare mortality by 28 days between hospitalized LTR and non-lung SOTR. Multivariable logistic regression models were used to assess comorbidity-adjusted mortality among LTR vs. non-lung SOTR and to determine risk factors for death in LTR. Of 1,616 SOTR with COVID-19, 1,081 (66%) were hospitalized including 120/159 (75%) LTR and 961/1457 (66%) non-lung SOTR (p = .02). Mortality was higher among LTR compared to non-lung SOTR (24% vs. 16%, respectively, p = .032), and lung transplant was independently associated with death after adjusting for age and comorbidities (aOR 1.7, 95% CI 1.0-2.6, p = .04). Among LTR, chronic lung allograft dysfunction (aOR 3.3, 95% CI 1.0-11.3, p = .05) was the only independent risk factor for mortality and age >65 years, heart failure and obesity were not independently associated with death. Among SOTR hospitalized for COVID-19, LTR had higher mortality than non-lung SOTR. In LTR, chronic allograft dysfunction was independently associated with mortality.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Organ Transplantation / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Adult / Aged / Humans Language: English Journal: Am J Transplant Journal subject: Transplantation Year: 2021 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Organ Transplantation / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Adult / Aged / Humans Language: English Journal: Am J Transplant Journal subject: Transplantation Year: 2021 Document Type: Article