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Effect of aspirin on short-term outcomes in hospitalized patients with COVID-19.
Sahai, Aditya; Bhandari, Rohan; Godwin, Matthew; McIntyre, Thomas; Chung, Mina K; Iskandar, Jean-Pierre; Kamran, Hayaan; Hariri, Essa; Aggarwal, Anu; Burton, Robert; Kalra, Ankur; Bartholomew, John R; McCrae, Keith R; Elbadawi, Ayman; Bena, James; Svensson, Lars G; Kapadia, Samir; Cameron, Scott J.
  • Sahai A; Section of Vascular Medicine, Department of Cardiovascular Medicine; Heart, Vascular & Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Bhandari R; Section of Vascular Medicine, Department of Cardiovascular Medicine; Heart, Vascular & Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Godwin M; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • McIntyre T; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Chung MK; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Iskandar JP; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Kamran H; Department of Cardiovascular Medicine; Heart, Vascular & Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Hariri E; Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA.
  • Aggarwal A; Section of Vascular Medicine, Department of Cardiovascular Medicine; Heart, Vascular & Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Burton R; Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA.
  • Kalra A; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Bartholomew JR; Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA.
  • McCrae KR; Section of Vascular Medicine, Department of Cardiovascular Medicine; Heart, Vascular & Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Elbadawi A; Section of Vascular Medicine, Department of Cardiovascular Medicine; Heart, Vascular & Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Bena J; Department of Cardiovascular Medicine; Heart, Vascular & Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Svensson LG; Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Kapadia S; Division of Cardiovascular Medicine, University of Texas Medical Branch, Galveston, TX, USA.
  • Cameron SJ; Department of Quantitative Health Science, Cleveland Clinic, Cleveland, OH, USA.
Vasc Med ; 26(6): 626-632, 2021 12.
Article in English | MEDLINE | ID: covidwho-1234444
ABSTRACT
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is an ongoing viral pandemic marked by increased risk of thrombotic events. However, the role of platelets in the elevated observed thrombotic risk in COVID-19 and utility of antiplatelet agents in attenuating thrombosis is unknown. We aimed to determine if the antiplatelet effect of aspirin may mitigate risk of myocardial infarction, cerebrovascular accident, and venous thromboembolism in COVID-19. We evaluated 22,072 symptomatic patients tested for COVID-19. Propensity-matched analyses were performed to determine if treatment with aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) affected thrombotic outcomes in COVID-19. Neither aspirin nor NSAIDs affected mortality in COVID-19. Thus, aspirin does not appear to prevent thrombosis and death in COVID-19. The mechanisms of thrombosis in COVID-19, therefore, appear distinct and the role of platelets as direct mediators of SARS-CoV-2-mediated thrombosis warrants further investigation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / Anti-Inflammatory Agents, Non-Steroidal / Aspirin / COVID-19 / Inpatients Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Vasc Med Journal subject: Vascular Diseases Year: 2021 Document Type: Article Affiliation country: 1358863X211012754

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / Anti-Inflammatory Agents, Non-Steroidal / Aspirin / COVID-19 / Inpatients Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Vasc Med Journal subject: Vascular Diseases Year: 2021 Document Type: Article Affiliation country: 1358863X211012754