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Neuron-specific enolase serum levels in COVID-19 are related to the severity of lung injury.
Cione, Erika; Siniscalchi, Antonio; Gangemi, Pietro; Cosco, Lucio; Colosimo, Manuela; Longhini, Federico; Luciani, Filippo; De Sarro, Giovambattista; Berrino, Liberato; D'Agostino, Bruno; Gallelli, Luca.
  • Cione E; Department of Pharmacy, Health and Nutritional Sciences-Department of Excellence 2018-2020, University of Calabria, Rende, Cosenza, Italy.
  • Siniscalchi A; Department of Neurology, Annunziata Hospital, Cosenza, Italy.
  • Gangemi P; Operative Unit of Clinical Chemistry Laboratory, Pugliese Ciaccio Hospital, Catanzaro, Italy.
  • Cosco L; Department of Infectious Disease, Pugliese Ciaccio Hospital, Catanzaro, Italy.
  • Colosimo M; Department of Microbiology and Virology, Pugliese Ciaccio Hospital, Catanzaro, Italy.
  • Longhini F; Department of Medical and Surgical Science, Operative Unit of Anesthesiology and Reanimation, School of Medicine, University of Catanzaro, Catanzaro, Italy.
  • Luciani F; Department of Infectious Disease, Annunziata Hospital, Cosenza, Italy.
  • De Sarro G; Department of Health Science, School of Medicine, Operative Unit of Clinical Pharmacology, Mater Domini University Hospital, University of Catanzaro, Catanzaro, Italy.
  • D'Agostino B; Department of Experimental Medicine L. Donatelli, Section of Pharmacology, School of Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
  • Gallelli L; Department of Experimental Medicine L. Donatelli, Section of Pharmacology, School of Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
PLoS One ; 16(5): e0251819, 2021.
Article in English | MEDLINE | ID: covidwho-1234591
ABSTRACT
The multifunctional role of neuron-specific enolase (NSE) in lung diseases is well established. As the lungs are greatly affected in COVID-19, we evaluated serum NSE levels in COVID-19 patients with and without dyspnea. In this study, we evaluated both SARS-CoV-2-infected and uninfected patients aged >18 years who were referred to hospitals in Catanzaro, Italy from March 30 to July 30, 2020. Epidemiological, clinical, and radiological characteristics, treatment, and outcome data were recorded and reviewed by a trained team of physicians. In total, 323 patients (178 men, 55.1% and 145 women, 44.9%) were enrolled; of these, 128 were COVID-19 patients (39.6%) and 195 were control patients (60.4%). Westergren's method was used to determine erythroid sedimentation rate. A chemiluminescence assay was used for measurement of interleukin-6, procalcitonin, C-reactive protein, and NSE. We detected significantly higher NSE values (P<0.05) in COVID-19 patients than in controls. Interestingly, within the COVID-19 group, we also observed a further significant increase in dyspnea (Dyspnea Scale and Exercise score 8.2 ± 0.8; scores ranging from 0 to 10, with higher numbers indicating very severe shortness of breath). These data provide the background for further investigations into the potential role of NSE as a clinical marker of COVID-19 progression.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Phosphopyruvate Hydratase / Lung Injury / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0251819

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Phosphopyruvate Hydratase / Lung Injury / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0251819