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Assessing Biocompatibility of Face Mask Materials during COVID-19 Pandemic by a Rapid Multi-Assays Strategy.
Petrachi, Tiziana; Ganzerli, Francesco; Cuoghi, Aurora; Ferrari, Alberto; Resca, Elisa; Bergamini, Valentina; Accorsi, Luca; Burini, Francesco; Pasini, Davide; Arnaud, Gaelle Françoise; Piccini, Mattia; Aldrovandi, Laura; Mari, Giorgio; Tomasi, Aldo; Rovati, Luigi; Dominici, Massimo; Veronesi, Elena.
  • Petrachi T; Technopole "Mario Veronesi", via 29 Maggio, 6, 41037 Mirandola, Italy.
  • Ganzerli F; Technopole "Mario Veronesi", via 29 Maggio, 6, 41037 Mirandola, Italy.
  • Cuoghi A; Technopole "Mario Veronesi", via 29 Maggio, 6, 41037 Mirandola, Italy.
  • Ferrari A; Technopole "Mario Veronesi", via 29 Maggio, 6, 41037 Mirandola, Italy.
  • Resca E; Department of Engineering "Enzo Ferrari", University of Modena and Reggio Emilia, via Vivarelli, 10, Building 26, 41124 Modena, Italy.
  • Bergamini V; Technopole "Mario Veronesi", via 29 Maggio, 6, 41037 Mirandola, Italy.
  • Accorsi L; Technopole "Mario Veronesi", via 29 Maggio, 6, 41037 Mirandola, Italy.
  • Burini F; Technopole "Mario Veronesi", via 29 Maggio, 6, 41037 Mirandola, Italy.
  • Pasini D; Technopole "Mario Veronesi", via 29 Maggio, 6, 41037 Mirandola, Italy.
  • Arnaud GF; Technopole "Mario Veronesi", via 29 Maggio, 6, 41037 Mirandola, Italy.
  • Piccini M; Technopole "Mario Veronesi", via 29 Maggio, 6, 41037 Mirandola, Italy.
  • Aldrovandi L; Technopole "Mario Veronesi", via 29 Maggio, 6, 41037 Mirandola, Italy.
  • Mari G; Department of Engineering "Enzo Ferrari", University of Modena and Reggio Emilia, via Vivarelli, 10, Building 26, 41124 Modena, Italy.
  • Tomasi A; Technopole "Mario Veronesi", via 29 Maggio, 6, 41037 Mirandola, Italy.
  • Rovati L; Technopole "Mario Veronesi", via 29 Maggio, 6, 41037 Mirandola, Italy.
  • Dominici M; Technopole "Mario Veronesi", via 29 Maggio, 6, 41037 Mirandola, Italy.
  • Veronesi E; Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, via del Pozzo, 71, 41124 Modena, Italy.
Int J Environ Res Public Health ; 18(10)2021 05 18.
Article in English | MEDLINE | ID: covidwho-1234733
ABSTRACT
During the coronavirus disease 2019 (COVID-19) pandemic, scientific authorities strongly suggested the use of face masks (FMs). FM materials (FMMs) have to satisfy the medical device biocompatibility requirements as indicated in the technical standard EN ISO 10993-12018. The biologic evaluation must be confirmed by in vivo tests to verify cytotoxicity, sensitisation, and skin irritation. Some of these tests require an extensive period of time for their execution, which is incompatible with an emergency situation. In this study, we propose to verify the safety of FMMs combining the assessment of 3-[4,5-dimethylthiazolyl-2]-2,5-diphenyltetrazolium bromide (MTT) with quantification of nitric oxide (NO) and interleukin-6 (IL-6), as predictive markers of skin sensitisation or irritation based on human primary fibroblasts. Two hundred and forty-two FMMs were collected and classified according to spectrometer IR in polypropylene, paper, cotton, polyester, polyethylene terephthalate, 3-dimensional printing, and viscose. Of all FMMs tested, 50.8% passed all the assays, 48% failed at least one, and only 1.2% failed all. By a low cost, rapid and highly sensitive multi assays strategy tested on human skin fibroblasts against a large variety of FMMs, we propose a strategy to promptly evaluate biocompatibility in wearable materials.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / COVID-19 Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijerph18105387

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / COVID-19 Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijerph18105387