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Viral PDZ Binding Motifs Influence Cell Behavior Through the Interaction with Cellular Proteins Containing PDZ Domains.
Castaño-Rodriguez, Carlos; Honrubia, Jose M; Gutiérrez-Álvarez, Javier; Sola, Isabel; Enjuanes, Luis.
  • Castaño-Rodriguez C; Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.
  • Honrubia JM; Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.
  • Gutiérrez-Álvarez J; Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.
  • Sola I; Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.
  • Enjuanes L; Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain. L.Enjuanes@cnb.csic.es.
Methods Mol Biol ; 2256: 217-236, 2021.
Article in English | MEDLINE | ID: covidwho-1235682
ABSTRACT
Viruses have evolved to interact with their hosts. Some viruses such as human papilloma virus, dengue virus, SARS-CoV, or influenza virus encode proteins including a PBM that interact with cellular proteins containing PDZ domains. There are more than 400 cellular protein isoforms with these domains in the human genome, indicating that viral PBMs have a high potential to influence the behavior of the cell. In this review we analyze the most relevant cellular processes known to be affected by viral PBM-cellular PDZ interactions including the establishment of cell-cell interactions and cell polarity, the regulation of cell survival and apoptosis and the activation of the immune system. Special attention has been provided to coronavirus PBM conservation throughout evolution and to the role of the PBMs of human coronaviruses SARS-CoV and MERS-CoV in pathogenesis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Proteins / Viruses / Virus Diseases / Cell Adhesion Molecules / Host-Pathogen Interactions Type of study: Prognostic study Limits: Humans Language: English Journal: Methods Mol Biol Journal subject: Molecular Biology Year: 2021 Document Type: Article Affiliation country: 978-1-0716-1166-1_13

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Proteins / Viruses / Virus Diseases / Cell Adhesion Molecules / Host-Pathogen Interactions Type of study: Prognostic study Limits: Humans Language: English Journal: Methods Mol Biol Journal subject: Molecular Biology Year: 2021 Document Type: Article Affiliation country: 978-1-0716-1166-1_13