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Effect of COVID-19 on liver abnormalities: a systematic review and meta-analysis.
Bzeizi, Khalid; Abdulla, Maheeba; Mohammed, Nafeesa; Alqamish, Jehad; Jamshidi, Negar; Broering, Dieter.
  • Bzeizi K; Department of Liver & Small Bowel Transplantation & Hepatobiliary-Pancreatic Surgery, King Faisal Specialist Hospital & Research Center, P.O. Box 3354, Riyadh, 11211, Saudi Arabia. kbzeizi@kfshrc.edu.sa.
  • Abdulla M; Internal Medicine Department, Salmaniya Medical Complex, Manama, Bahrain.
  • Mohammed N; Internal Medicine Department, Salmaniya Medical Complex, Manama, Bahrain.
  • Alqamish J; Ibn AlNafees Hospital, Manama, Bahrain.
  • Jamshidi N; School of Science, RMIT University, Melbourne, VIC, 3000, Australia.
  • Broering D; Organ Transplant Center & Department of Surgery, King Faisal Specialist Hospital & Research Centre (Gen. Org) MBC 96, AlFaisal University, P.O. Box 3354, Riyadh, 11211, Saudi Arabia.
Sci Rep ; 11(1): 10599, 2021 05 19.
Article in English | MEDLINE | ID: covidwho-1236092
ABSTRACT
Emerging evidence suggest association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with the development of many liver abnormalities. The overarching aim of this study was therefore to assess the available evidence on the clinical effects of SARS-CoV-2 on the profiles of liver chemistries and coagulation in COVID-19 diagnosed patients. We considered all study designs including epidemiological and observational that reported liver function test abnormalities in patients confirmed with SARS-CoV-2 infection. Medline, Embase databases and Google Scholar as well as relevant reviews were searched to identify appropriate studies from inception to 31st of August 2020. We calculated the pooled mean with 95% confidence intervals (95% CI) through a random-effect model meta-analysis. A total of 35 studies with 10,692 participants were considered for the review from which 23 studies with sufficient quantitative data were included in the meta-analysis. The pooled mean for liver enzymes and coagulation parameters did not significantly change in patients diagnosed with COVID-19 and remained within normal range. Notwithstanding potential bias from confounding factors in interpretation of data in this review, findings from the observational studies and case reports suggest that COVID-19 does not appear to have a significant impact on the transaminases or total bilirubin levels of patients with confirmed SARS-CoV-2 infection. Further controlled studies and larger sample size observational studies are needed with adequate reporting of other liver function parameters are warranted.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Liver Diseases Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-89513-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Liver Diseases Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-89513-9