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Pathogenesis guided therapeutic management of COVID-19: an immunological perspective.
Kumar, Ashutosh; Prasoon, Pranav; Sekhawat, Prakash S; Pareek, Vikas; Faiq, Muneeb A; Kumari, Chiman; Narayan, Ravi K; Kulandhasamy, Maheswari; Kant, Kamla.
  • Kumar A; Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India.
  • Prasoon P; Department of Anatomy, All India Institute of Medical Sciences (AIIMS), Patna, India.
  • Sekhawat PS; Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India.
  • Pareek V; Pittsburgh Center for Pain Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Faiq MA; Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India.
  • Kumari C; Department of Hematology, Nil RatanSircar Medical College and Hospital (NRSMCH), Kolkata, India.
  • Narayan RK; Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India.
  • Kulandhasamy M; National Brain Research Center, Manesar, Haryana, India.
  • Kant K; Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India.
Int Rev Immunol ; 40(1-2): 54-71, 2021.
Article in English | MEDLINE | ID: covidwho-1236149
ABSTRACT
Lack of standardized therapeutic approaches is arguably the significant contributor to the high burden of mortality observed in the ongoing pandemic of the Coronavirus disease, 2019 (COVID-19). Evidence is accumulating on SARS-CoV-2 specific immune cell dysregulation and consequent tissue injury in COVID-19. Currently, no definite drugs or vaccines are available against the disease; however initial results of the ongoing clinical trials have raised some hope. In this article, taking insights from the emerging empirical evidence about host-virus interactions, we deliberate upon plausible pathogenic mechanisms and suitable therapeutic approaches for COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 / Immunity, Innate Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Int Rev Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: 08830185.2020.1840566

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 / Immunity, Innate Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Int Rev Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: 08830185.2020.1840566