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Insights from Patterns of SARS-CoV-2 Immunoglobulin G Serology Test Results from a National Clinical Laboratory, United States, March-July 2020.
Kaufman, Harvey W; Chen, Zhen; Meyer, William A; Wohlgemuth, Jay G.
  • Kaufman HW; Quest Diagnostics, Secaucus, New Jersey, USA.
  • Chen Z; Quest Diagnostics, Secaucus, New Jersey, USA.
  • Meyer WA; Quest Diagnostics, Secaucus, New Jersey, USA.
  • Wohlgemuth JG; Quest Diagnostics, Secaucus, New Jersey, USA.
Popul Health Manag ; 24(S1): S35-S42, 2021 02.
Article in English | MEDLINE | ID: covidwho-1236196
ABSTRACT
Serologic tests for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) provide information on past infection and immune response. To better understand the persistence of immune response and the proportion of the population who can develop one, the authors assessed patterns of immunoglobulin G (IgG) positivity over time in individuals tested for SARS-CoV-2 RNA or IgG at a large national reference laboratory. More than 2.4 million SARS-CoV-2 IgG serology (initiated April 21, 2020) and 6.6 million nucleic acid amplification testing (NAAT) (initiated March 9, 2020) results on persons from across the United States as of July 10, 2020 were analyzed. Additional IgG serology results through August 11, 2020 were used for one household analysis. SARS-CoV-2 IgG positivity was observed in 91% (19,434/21,452) of individuals tested after a positive NAAT result and in 10% (7,831/80,968) after a negative NAAT result. Factors associated with seropositivity include age, region of patient residence, and interval between NAAT and IgG serology. The probability of persistent IgG seropositivity declined from 98.6% after 1 week to 74.3% after 2 months, less so in individuals ages ≥55 years than in younger groups. Specimens within 2 days from pairs of same-household members showed 92% IgG antibody concordance. Household adults were more frequently IgG positive prior to household children testing positive (36% versus 8%). IgG serology testing can identify an immune response to SARS-CoV-2 that varies based on age, sex, and duration since exposure. Loss of detectable IgG seropositivity occurs, in some patients, over weeks or months. Adults may be infecting household children.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: North America Language: English Journal: Popul Health Manag Journal subject: Public Health / Health Services Year: 2021 Document Type: Article Affiliation country: Pop.2020.0256

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: North America Language: English Journal: Popul Health Manag Journal subject: Public Health / Health Services Year: 2021 Document Type: Article Affiliation country: Pop.2020.0256