Your browser doesn't support javascript.
Corticosteroid therapy for COVID-19: A systematic review and meta-analysis of randomized controlled trials.
Pulakurthi, Yashwitha Sai; Pederson, John M; Saravu, Kavitha; Gupta, Nitin; Balasubramanian, Prasanth; Kamrowski, Shelby; Schmidt, Megan; Vegivinti, Charan Thej Reddy; Dibas, Mahmoud; Reierson, Natalie L; Pisipati, Sailaja; Joseph, Betsy Ann; Selvan, Pragadeesh Thamarai; Dmytriw, Adam A; Keesari, Praneeth Reddy; Sriram, Varsha; Chittajallu, Spandana; Brinjikji, Waleed; Katamreddy, Rewanth R; Chibbar, Richa; Davis, Amber R; Malpe, Manashree; Mishra, Hemant K; Kallmes, Kevin M; Hassan, Ameer E; Evanson, Kirk W.
  • Pulakurthi YS; Kamineni Academy of Medical Sciences and Research Centre, Hyderabad, Telangana, India.
  • Pederson JM; Nested Knowledge, St. Paul, MN.
  • Saravu K; Department of Infectious Diseases, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India.
  • Gupta N; Department of Infectious Diseases, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India.
  • Balasubramanian P; Department of Internal Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY.
  • Kamrowski S; Nested Knowledge, St. Paul, MN.
  • Schmidt M; Nested Knowledge, St. Paul, MN.
  • Vegivinti CTR; Department of General Medicine, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India.
  • Dibas M; Sulaiman Al Rajhi University, College of Medicine, Saudi Arabia.
  • Reierson NL; Nested Knowledge, St. Paul, MN.
  • Pisipati S; Department of Gastroenterology, Mayo Clinic, Scottsdale, AZ.
  • Joseph BA; Nested Knowledge, St. Paul, MN.
  • Selvan PT; Department of General Medicine, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India.
  • Dmytriw AA; Neuroradiology & Neurointervention Service, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  • Keesari PR; Kamineni Academy of Medical Sciences and Research Centre, Hyderabad, Telangana, India.
  • Sriram V; Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India.
  • Chittajallu S; Rangaraya Medical College, Kakinada, Andhra Pradesh, India.
  • Brinjikji W; Department of Radiology, Mayo Clinic, Rochester, MN.
  • Katamreddy RR; Department of General Surgery, Kempegowda Institute of Medical Sciences, Bangalore, Karnataka, India.
  • Chibbar R; Department of Medicine, Lakeridge Health, Oshawa, ON, Canada.
  • Davis AR; Superior Medical Experts, St. Paul.
  • Malpe M; Superior Medical Experts, St. Paul.
  • Mishra HK; University of Minnesota, Twin Cities, MN.
  • Kallmes KM; Nested Knowledge, St. Paul, MN.
  • Hassan AE; Department of Neuroradiology, Valley Baptist Medical Center-Harlingen, Texas.
  • Evanson KW; Superior Medical Experts, St. Paul.
Medicine (Baltimore) ; 100(20): e25719, 2021 May 21.
Article in English | MEDLINE | ID: covidwho-1236278
Semantic information from SemMedBD (by NLM)
1. Steroid therapy TREATS COVID-19
Subject
Steroid therapy
Predicate
TREATS
Object
COVID-19
2. Adrenal Cortex Hormones TREATS COVID-19
Subject
Adrenal Cortex Hormones
Predicate
TREATS
Object
COVID-19
3. Placebos ADMINISTERED_TO Patients
Subject
Placebos
Predicate
ADMINISTERED_TO
Object
Patients
4. Adrenal Cortex Hormones ADMINISTERED_TO Patients
Subject
Adrenal Cortex Hormones
Predicate
ADMINISTERED_TO
Object
Patients
5. Patients LOCATION_OF GJA1 gene|GJA1
Subject
Patients
Predicate
LOCATION_OF
Object
GJA1 gene|GJA1
6. Mechanical ventilation TREATS COVID-19
Subject
Mechanical ventilation
Predicate
TREATS
Object
COVID-19
7. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
8. Mechanical ventilation TREATS Patients
Subject
Mechanical ventilation
Predicate
TREATS
Object
Patients
9. Steroid therapy TREATS COVID-19
Subject
Steroid therapy
Predicate
TREATS
Object
COVID-19
10. Adrenal Cortex Hormones TREATS COVID-19
Subject
Adrenal Cortex Hormones
Predicate
TREATS
Object
COVID-19
11. Placebos ADMINISTERED_TO Patients
Subject
Placebos
Predicate
ADMINISTERED_TO
Object
Patients
12. Adrenal Cortex Hormones ADMINISTERED_TO Patients
Subject
Adrenal Cortex Hormones
Predicate
ADMINISTERED_TO
Object
Patients
13. Patients LOCATION_OF GJA1 gene|GJA1
Subject
Patients
Predicate
LOCATION_OF
Object
GJA1 gene|GJA1
14. Mechanical ventilation TREATS COVID-19
Subject
Mechanical ventilation
Predicate
TREATS
Object
COVID-19
15. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
16. Mechanical ventilation TREATS Patients
Subject
Mechanical ventilation
Predicate
TREATS
Object
Patients
ABSTRACT

BACKGROUND:

Corticosteroid treatment is an effective and common therapeutic strategy for various inflammatory lung pathologies and may be an effective treatment for coronavirus disease 2019 (COVID-19). The purpose of this systematic review and meta-analysis of current literature was to investigate the clinical outcomes associated with corticosteroid treatment of COVID-19.

METHODS:

We systematically searched PubMed, medRxiv, Web of Science, and Scopus databases through March 10, 2021 to identify randomized controlled trials (RCTs) that evaluated the effects of corticosteroid therapies for COVID-19 treatment. Outcomes of interest were mortality, need for mechanical ventilation, serious adverse events (SAEs), and superinfection.

RESULTS:

A total of 7737 patients from 8 RCTs were included in the quantitative meta-analysis, of which 2795 (36.1%) patients received corticosteroids plus standard of care (SOC) while 4942 (63.9%) patients received placebo and/or SOC alone. The odds of mortality were significantly lower in patients that received corticosteroids as compared to SOC (odds ratio [OR] = 0.85 [95% CI 0.76; 0.95], P = .003). Corticosteroid treatment reduced the odds of a need for mechanical ventilation as compared to SOC (OR = 0.76 [95% CI 0.59; 0.97], P = .030). There was no significant difference between the corticosteroid and SOC groups with regards to SAEs and superinfections.

CONCLUSION:

Corticosteroid treatment can reduce the odds for mortality and the need for mechanical ventilation in severe COVID-19 patients.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Adrenal Cortex Hormones / COVID-19 Type of study: Controlled clinical trial / Etiology study / Randomized controlled trials / Reviews / Systematic review Limits: Humans Language: English Journal: Medicine (Baltimore) Year: 2021 Document Type: Article Affiliation country: MD.0000000000025719

Full text: Available Collection: International databases Database: MEDLINE Main subject: Adrenal Cortex Hormones / COVID-19 Type of study: Controlled clinical trial / Etiology study / Randomized controlled trials / Reviews / Systematic review Limits: Humans Language: English Journal: Medicine (Baltimore) Year: 2021 Document Type: Article Affiliation country: MD.0000000000025719