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Biochemical abnormalities in COVID-19: a comparison of white versus ethnic minority populations in the UK.
Taylor, David R; Buchanan, Devon; Al-Hasani, Wiaam; Kearney, Jessica; Mazaheri, Tina; Ranasinghe, Ruvini N K; Dimitriadis, Georgios K; Vincent, Royce P.
  • Taylor DR; Department of Clinical Biochemistry, King's College Hospital NHS Foundation Trust, London, UK davidtaylor8@nhs.net.
  • Buchanan D; Department of Clinical Biochemistry, King's College Hospital NHS Foundation Trust, London, UK.
  • Al-Hasani W; Department of Clinical Biochemistry, King's College Hospital NHS Foundation Trust, London, UK.
  • Kearney J; Department of Endocrinology, King's College Hospital NHS Foundation Trust, London, UK.
  • Mazaheri T; Department of Clinical Biochemistry, King's College Hospital NHS Foundation Trust, London, UK.
  • Ranasinghe RNK; Department of Clinical Biochemistry, King's College Hospital NHS Foundation Trust, London, UK.
  • Dimitriadis GK; Department of Endocrinology, King's College Hospital NHS Foundation Trust, London, UK.
  • Vincent RP; Department of Clinical Biochemistry, King's College Hospital NHS Foundation Trust, London, UK.
J Clin Pathol ; 2021 May 19.
Article in English | MEDLINE | ID: covidwho-2283691
ABSTRACT

AIMS:

Public Health England has identified that in COVID-19, death rates among ethnic minorities far exceeds that of the white population. While the increase in ethnic minorities is likely to be multifactorial, to date, no studies have looked to see whether values for routine clinical biochemistry parameters differ between ethnic minority and white individuals.

METHODS:

Baseline biochemical data for 22 common tests from 311 SARS-CoV-2 positive patients presenting to hospital in April 2020 in whom ethnicity data were available was retrospectively collected and evaluated. Data comparisons between ethnic minority and white groups were made for all patient data and for the subset of patients subsequently admitted to intensive care.

RESULTS:

When all patient data were considered, the ethnic minority population had statistically significant higher concentrations of C reactive protein (CRP), aspartate aminotransferase and gamma-glutamyl transferase, while troponin T was higher in the white group. A greater proportion of ethnic minority patients were subsequently admitted to intensive care, but when the presenting biochemistry of this subset of patients was compared, no significant differences were observed between ethnic minority and white groups.

CONCLUSION:

Our data show for the first time that routine biochemistry at hospital presentation in COVID-19 differs between ethnic minority and white groups. Among the markers identified, CRP was significantly higher in the ethnic minority group pointing towards an increased tendency for severe inflammation in this group.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Language: English Year: 2021 Document Type: Article Affiliation country: Jclinpath-2021-207446

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Language: English Year: 2021 Document Type: Article Affiliation country: Jclinpath-2021-207446