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Natural Products Modulating Angiotensin Converting Enzyme 2 (ACE2) as Potential COVID-19 Therapies.
Abubakar, Murtala Bello; Usman, Dawoud; El-Saber Batiha, Gaber; Cruz-Martins, Natália; Malami, Ibrahim; Ibrahim, Kasimu Ghandi; Abubakar, Bilyaminu; Bello, Muhammad Bashir; Muhammad, Aliyu; Gan, Siew Hua; Dabai, Aliyu Ibrahim; Alblihed, M; Ghosh, Arabinda; Badr, Reem H; Thangadurai, Devarajan; Imam, Mustapha Umar.
  • Abubakar MB; Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
  • Usman D; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto, Nigeria.
  • El-Saber Batiha G; Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
  • Cruz-Martins N; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto, Nigeria.
  • Malami I; Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt.
  • Ibrahim KG; Faculty of Medicine, University of Porto, Porto, Portugal.
  • Abubakar B; Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal.
  • Bello MB; Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal.
  • Muhammad A; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto, Nigeria.
  • Gan SH; Department of Pharmacognosy and Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
  • Dabai AI; Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
  • Alblihed M; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto, Nigeria.
  • Ghosh A; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto, Nigeria.
  • Badr RH; Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
  • Thangadurai D; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto, Nigeria.
  • Imam MU; Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria.
Front Pharmacol ; 12: 629935, 2021.
Article in English | MEDLINE | ID: covidwho-1236736
ABSTRACT
The 2019 coronavirus disease (COVID-19) is a potentially fatal multisystemic infection caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Currently, viable therapeutic options that are cost effective, safe and readily available are desired, but lacking. Nevertheless, the pandemic is noticeably of lesser burden in African and Asian regions, where the use of traditional herbs predominates, with such relationship warranting a closer look at ethnomedicine. From a molecular viewpoint, the interaction of SARS-CoV-2 with angiotensin converting enzyme 2 (ACE2) is the crucial first phase of COVID-19 pathogenesis. Here, we review plants with medicinal properties which may be implicated in mitigation of viral invasion either via direct or indirect modulation of ACE2 activity to ameliorate COVID-19. Selected ethnomedicinal plants containing bioactive compounds which may prevent and mitigate the fusion and entry of the SARS-CoV-2 by modulating ACE2-associated up and downstream events are highlighted. Through further experimentation, these plants could be supported for ethnobotanical use and the phytomedicinal ligands could be potentially developed into single or combined preventive therapeutics for COVID-19. This will benefit researchers actively looking for solutions from plant bioresources and help lessen the burden of COVID-19 across the globe.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Traditional medicine Language: English Journal: Front Pharmacol Year: 2021 Document Type: Article Affiliation country: Fphar.2021.629935

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Full text: Available Collection: International databases Database: MEDLINE Topics: Traditional medicine Language: English Journal: Front Pharmacol Year: 2021 Document Type: Article Affiliation country: Fphar.2021.629935