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Biological and Clinical Factors contributing to the Metabolic Heterogeneity of Hospitalized Patients with and without COVID-19.
D'Alessandro, Angelo; Akpan, Imo; Thomas, Tiffany; Reisz, Julie; Cendali, Francesca; Gamboni, Fabia; Nemkov, Travis; Thangaraju, Kiruphagaran; Katneni, Upendra; Tanaka, Kenichi; Kahn, Stacie; Wei, Alexander; Valk, Jacob; Hudson, Krystalyn; Roh, David; Moriconi, Chiara; Zimring, James; Hod, Eldad; Spitalnik, Steven; Buehler, Paul; Francis, Richard.
  • D'Alessandro A; University of Colorado Denver.
  • Akpan I; Columbia University Irving Medical Center.
  • Thomas T; Columbia University.
  • Reisz J; University of Colorado Denver.
  • Cendali F; University of Colorado Denver.
  • Gamboni F; University of Colorado Denver.
  • Nemkov T; Department of Biochemistry and Molecular Genetics, University of Colorado Denver.
  • Thangaraju K; University of Maryland.
  • Katneni U; University of Maryland.
  • Tanaka K; University of Maryland.
  • Kahn S; Columbia University Irving Medical Center.
  • Wei A; Columbia University Irving Medical Center.
  • Valk J; Columbia University Irving Medical Center.
  • Hudson K; Columbia University Medical Center.
  • Roh D; Columbia University.
  • Moriconi C; Columbia University Irving Medical Center.
  • Zimring J; University of Virginia.
  • Hod E; Columbia University.
  • Spitalnik S; Columbia University Irving Medical Center.
  • Buehler P; University of Maryland.
  • Francis R; Columbia University Irving Medical Center.
Res Sq ; 2021 May 10.
Article in English | MEDLINE | ID: covidwho-1237041
Preprint
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ABSTRACT
The Corona Virus Disease 2019 (COVID-19) pandemic represents an ongoing worldwide challenge. Exploratory studies evaluating the impact of COVID-19 infection on the plasma metabolome have been performed, often with small numbers of patients, and with or without relevant control data; however, determining the impact of biological and clinical variables remains critical to understanding potential markers of disease severity and progression. The present large study, including relevant controls, sought to understand independent and overlapping metabolic features of samples from acutely ill patients (n = 831), testing positive (n = 543) or negative (n = 288) for COVID-19. High-throughput metabolomics analyses were complemented with antigen and enzymatic activity assays on 831 plasma samples from acutely ill patients while in the emergency department, at admission, and during hospitalization. We then performed additional lipidomics analyses of the 60 subjects with the lowest and highest body mass index, either COVID-19 positive or negative. Omics data were correlated to detailed data on patient characteristics and clinical laboratory assays measuring coagulation, hematology and chemistry analytes. Significant changes in arginine/proline/citrulline, tryptophan/indole/kynurenine, fatty acid and acyl-carnitine metabolism emerged as highly relevant markers of disease severity, progression and prognosis as a function of biological and clinical variables in these patients. Further, machine learning models were trained by entering all metabolomics and clinical data from half of the COVID-19 patient cohort and then tested on the other half yielding ~ 78% prediction accuracy. Finally, the extensive amount of information accumulated in this large, prospective, observational study provides a foundation for follow-up mechanistic studies and data sharing opportunities, which will advance our understanding of the characteristics of the plasma metabolism in COVID-19 and other acute critical illnesses.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Year: 2021 Document Type: Article