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SARS-CoV-2 causing pneumonia-associated respiratory disorder (COVID-19): diagnostic and proposed therapeutic options.
Chakraborty, C; Sharma, A R; Sharma, G; Bhattacharya, M; Lee, S S.
  • Chakraborty C; Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Korea. drchiranjib@yahoo.com.
Eur Rev Med Pharmacol Sci ; 24(7): 4016-4026, 2020 04.
Article in English | MEDLINE | ID: covidwho-123794
Semantic information from SemMedBD (by NLM)
1. Severe Acute Respiratory Syndrome COEXISTS_WITH Disease
Subject
Severe Acute Respiratory Syndrome
Predicate
COEXISTS_WITH
Object
Disease
2. Severe Acute Respiratory Syndrome INTERACTS_WITH 2019 novel coronavirus
Subject
Severe Acute Respiratory Syndrome
Predicate
INTERACTS_WITH
Object
2019 novel coronavirus
3. Severe Acute Respiratory Syndrome COEXISTS_WITH Disease
Subject
Severe Acute Respiratory Syndrome
Predicate
COEXISTS_WITH
Object
Disease
4. Severe Acute Respiratory Syndrome INTERACTS_WITH 2019 novel coronavirus
Subject
Severe Acute Respiratory Syndrome
Predicate
INTERACTS_WITH
Object
2019 novel coronavirus
ABSTRACT
SARS-CoV-2 is responsible for the outbreak of severe respiratory illness (COVID-19) in Wuhan City, China and is now spreading rapidly throughout the world. The prompt outbreak of COVID-19 and its quick spread without any controllable measure defines the severity of the situation. In this crisis, a collective pool of knowledge about the advancement of clinical diagnostic and management for COVID-19 is a prerequisite. Here, we summarize all the available updates on the multidisciplinary approaches for the advancement of diagnosis and proposed therapeutic strategies for COVID-19. Moreover, the review discusses different aspects of the COVID-19, including its epidemiology; incubation period; the general clinical features of patients; the clinical features of intensive care unit (ICU) patients; SARS-CoV-2 infection in the presence of co-morbid diseases and the clinical features of pediatric patients infected with the SARS-CoV-2. Advances in various diagnostic approaches, such as the use of real-time polymerase chain reaction (RT-PCR), chest radiography, and computed tomography (CT) imaging; and other modern diagnostic methods, for this infection have been highlighted. However, due to the unavailability of adequate evidence, presently there are no officially approved drugs or vaccines available against SARS-CoV-2. Additionally, we have discussed various therapeutic strategies for COVID-19 under different categories, like the possible treatment plans with drug (antiviral drugs and anti-cytokines) therapy for disease prevention. Lastly, potentials candidates for the vaccines against SARS-CoV-2 infection have been described. Collectively, the review provides an overview of the SARS-CoV-2 infection outbreak along with the recent advancements and strategies for diagnosis and therapy of COVID-19.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections Type of study: Diagnostic study / Risk factors Limits: Humans Language: English Journal: Eur Rev Med Pharmacol Sci Journal subject: Pharmacology / Toxicology Year: 2020 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections Type of study: Diagnostic study / Risk factors Limits: Humans Language: English Journal: Eur Rev Med Pharmacol Sci Journal subject: Pharmacology / Toxicology Year: 2020 Document Type: Article