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ACE2 glycans preferentially interact with SARS-CoV-2 over SARS-CoV.
Acharya, Atanu; Lynch, Diane L; Pavlova, Anna; Pang, Yui Tik; Gumbart, James C.
  • Acharya A; School of Physics, Georgia Institute of Technology, Atlanta, GA 30332, USA. aacharya42@gatech.edu gumbart@physics.gatech.edu.
  • Lynch DL; School of Physics, Georgia Institute of Technology, Atlanta, GA 30332, USA. aacharya42@gatech.edu gumbart@physics.gatech.edu.
  • Pavlova A; School of Physics, Georgia Institute of Technology, Atlanta, GA 30332, USA. aacharya42@gatech.edu gumbart@physics.gatech.edu.
  • Pang YT; School of Physics, Georgia Institute of Technology, Atlanta, GA 30332, USA. aacharya42@gatech.edu gumbart@physics.gatech.edu.
  • Gumbart JC; School of Physics, Georgia Institute of Technology, Atlanta, GA 30332, USA. aacharya42@gatech.edu gumbart@physics.gatech.edu.
Chem Commun (Camb) ; 57(48): 5949-5952, 2021 Jun 15.
Article in English | MEDLINE | ID: covidwho-1238024
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ABSTRACT
We report a distinct difference in the interactions of the glycans of the host-cell receptor, ACE2, with SARS-CoV-2 and SARS-CoV S-protein receptor-binding domains (RBDs). Our analysis demonstrates that the ACE2 glycan at N322 enhances interactions with the SARS-CoV-2 RBD while the ACE2 glycan at N90 may offer protection against infections of both coronaviruses depending on its composition. The interactions of the ACE2 glycan at N322 with SARS-CoV RBD are blocked by the presence of the RBD glycan at N357 of the SARS-CoV RBD. The absence of this glycosylation site on SARS-CoV-2 RBD may enhance its binding with ACE2.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Polysaccharides / Severe acute respiratory syndrome-related coronavirus / Spike Glycoprotein, Coronavirus / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 Limits: Humans Language: English Journal: Chem Commun (Camb) Journal subject: Chemistry Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Polysaccharides / Severe acute respiratory syndrome-related coronavirus / Spike Glycoprotein, Coronavirus / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 Limits: Humans Language: English Journal: Chem Commun (Camb) Journal subject: Chemistry Year: 2021 Document Type: Article