Tranilast: a potential anti-Inflammatory and NLRP3 inflammasome inhibitor drug for COVID-19.
Immunopharmacol Immunotoxicol
; 43(3): 247-258, 2021 Jun.
Article
in English
| MEDLINE | ID: covidwho-1238099
ABSTRACT
SARS-CoV-2 is a type of beta-CoV that develops acute pneumonia, which is an inflammatory condition. A cytokine storm has been recognized as one of the leading causes of death in patients with COVID-19. ALI and ARDS along with multiple organ failure have also been presented as the consequences of acute inflammation and cytokine storm. It has been previously confirmed that SARS-CoV, as another member of the beta-CoV family, activates NLRP3 inflammasome and consequently develops acute inflammation in a variety of ways through having complex interactions with the host immune system using structural and nonstructural proteins. Numerous studies conducted on Tranilast have further demonstrated that the given drug can act as an effective anti-chemotactic factor on controlling inflammation, and thus, it can possibly help the improvement of the acute form of COVID-19 by inhibiting some key inflammation-associated transcription factors such as NF-κB and impeding NLRP3 inflammasome. Several studies have comparably revealed the direct effect of this drug on the prevention of inappropriate tissue's remodeling; inhibition of neutrophils, IL-5, and eosinophils; repression of inflammatory cell infiltration into inflammation site; restriction of factors involved in acute airway inflammation like IL-33; and suppression of cytokine IL-13, which increase mucosal secretions. Therefore, Tranilast may be considered as a potential treatment for patients with the acute form of COVID-19 along with other drugs.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Inflammasomes
/
Ortho-Aminobenzoates
/
NLR Family, Pyrin Domain-Containing 3 Protein
/
SARS-CoV-2
/
COVID-19 Drug Treatment
/
Anti-Inflammatory Agents
Limits:
Humans
Language:
English
Journal:
Immunopharmacol Immunotoxicol
Journal subject:
Allergy and Immunology
/
Pharmacology
/
Toxicology
Year:
2021
Document Type:
Article
Affiliation country:
08923973.2021.1925293
Similar
MEDLINE
...
LILACS
LIS