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Chronic respiratory diseases are predictors of severe outcome in COVID-19 hospitalised patients: a nationwide study.
Beltramo, Guillaume; Cottenet, Jonathan; Mariet, Anne-Sophie; Georges, Marjolaine; Piroth, Lionel; Tubert-Bitter, Pascale; Bonniaud, Philippe; Quantin, Catherine.
  • Beltramo G; Reference Constitutive Center for Rare Lung Diseases, Dept of Pulmonary Medicine and Intensive Care Unit, University Hospital, Dijon, France.
  • Cottenet J; INSERM LNC-UMR 1231, Dijon, France.
  • Mariet AS; University of Bourgogne-Franche-Comté, Dijon, France.
  • Georges M; These authors contributed equally to this work.
  • Piroth L; University of Bourgogne-Franche-Comté, Dijon, France.
  • Tubert-Bitter P; Biostatistics and Bioinformatics (DIM), Dijon University Hospital, Dijon, France.
  • Bonniaud P; These authors contributed equally to this work.
  • Quantin C; University of Bourgogne-Franche-Comté, Dijon, France.
Eur Respir J ; 58(6)2021 12.
Article in English | MEDLINE | ID: covidwho-1238699
Semantic information from SemMedBD (by NLM)
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Chronic disease of respiratory system
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Patients
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Lung diseases
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Patients
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Influenza
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Asthma
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Patients
5. Cystic Fibrosis PROCESS_OF Patients
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Cystic Fibrosis
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6. Pulmonary Hypertension PROCESS_OF Patients
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Pulmonary Hypertension
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Patients
7. Chronic Obstructive Airway Disease PROCESS_OF Patients
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Chronic Obstructive Airway Disease
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PROCESS_OF
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Patients
8. Chronic respiratory failure PROCESS_OF Patients
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Chronic respiratory failure
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Patients
9. COVID-19 PROCESS_OF Patients
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COVID-19
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PROCESS_OF
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Patients
10. Pulmonary Embolism PROCESS_OF Patients
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Pulmonary Embolism
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Patients
11. Pneumoni PROCESS_OF C0030705
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Pneumoni
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C0030705
12. Respiration Disorders PROCESS_OF Patients
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Respiration Disorders
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PROCESS_OF
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Patients
13. Chronic disease of respiratory system PROCESS_OF Patients
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Chronic disease of respiratory system
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Patients
14. Lung diseases PROCESS_OF Patients
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Lung diseases
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Patients
15. Influenza PROCESS_OF Patients
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Influenza
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Patients
16. Asthma PROCESS_OF Patients
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Asthma
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PROCESS_OF
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Patients
17. Cystic Fibrosis PROCESS_OF Patients
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Cystic Fibrosis
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PROCESS_OF
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Patients
18. Pulmonary Hypertension PROCESS_OF Patients
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Pulmonary Hypertension
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Patients
19. Chronic Obstructive Airway Disease PROCESS_OF Patients
Subject
Chronic Obstructive Airway Disease
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PROCESS_OF
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Patients
20. Chronic respiratory failure PROCESS_OF Patients
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Chronic respiratory failure
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PROCESS_OF
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Patients
21. COVID-19 PROCESS_OF Patients
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COVID-19
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Patients
22. Pulmonary Embolism PROCESS_OF Patients
Subject
Pulmonary Embolism
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PROCESS_OF
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Patients
23. Pneumonia, Ventilator-Associated PROCESS_OF Patients
Subject
Pneumonia, Ventilator-Associated
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Patients
24. Respiration Disorders PROCESS_OF Patients
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Respiration Disorders
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ABSTRACT

BACKGROUND:

Influenza epidemics were initially considered to be a suitable model for the COVID-19 epidemic, but there is a lack of data concerning patients with chronic respiratory diseases (CRDs), who were supposed to be at risk of severe forms of COVID-19.

METHODS:

This nationwide retrospective cohort study describes patients with prior lung disease hospitalised for COVID-19 (March-April 2020) or influenza (2018-2019 influenza outbreak). We compared the resulting pulmonary complications, need for intensive care and in-hospital mortality depending on respiratory history and virus.

RESULTS:

In the 89 530 COVID-19 cases, 16.03% had at least one CRD, which was significantly less frequently than in the 45 819 seasonal influenza patients. Patients suffering from chronic respiratory failure, chronic obstructive pulmonary disease, asthma, cystic fibrosis and pulmonary hypertension were under-represented, contrary to those with lung cancer, sleep apnoea, emphysema and interstitial lung diseases. COVID-19 patients with CRDs developed significantly more ventilator-associated pneumonia and pulmonary embolism than influenza patients. They needed intensive care significantly more often and had a higher mortality rate (except for asthma) when compared with patients with COVID-19 but without CRDs or patients with influenza.

CONCLUSIONS:

Patients with prior respiratory diseases were globally less likely to be hospitalised for COVID-19 than for influenza, but were at higher risk of developing severe COVID-19 and had a higher mortality rate compared with influenza patients and patients without a history of respiratory illness.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza, Human / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: 13993003.04474-2020

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza, Human / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: 13993003.04474-2020