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Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and Immunomodulation.
Schijns, Virgil; Majhen, Dragomira; van der Ley, Peter; Thakur, Aneesh; Summerfield, Artur; Berisio, Rita; Nativi, Cristina; Fernández-Tejada, Alberto; Alvarez-Dominguez, Carmen; Gizurarson, Sveinbjörn; Zamyatina, Alla; Molinaro, Antonio; Rosano, Camillo; Jakopin, Ziga; Gursel, Ihsan; McClean, Siobhán.
  • Schijns V; Intravacc, Institute for Translational Vaccinology (Intravacc), Utrecht Science Park, 3721 MA Bilthoven, The Netherlands.
  • Majhen D; Epitopoietic Research Corporation (ERC), 5374 RE Schaijk, The Netherlands.
  • van der Ley P; Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruder Boskovic Instiute, HR-10000 Zagreb, Croatia.
  • Thakur A; Intravacc, Institute for Translational Vaccinology (Intravacc), Utrecht Science Park, 3721 MA Bilthoven, The Netherlands.
  • Summerfield A; Department of Pharmacy, University of Copenhagen, 2100 Copenhagen, Denmark.
  • Berisio R; Institute of Virology and Immunology, 3147 Mittelhausern, Switzerland.
  • Nativi C; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.
  • Fernández-Tejada A; Institute of Biostructures and Bioimaging, National Research Council, I-80134 Naples, Italy.
  • Alvarez-Dominguez C; Department of Chemistry "Ugo Schiff", University of Florence, 50019 Sesto Fiorentino, Italy.
  • Gizurarson S; Chemical Immunology Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Biscay Science and Technology Park, 48160 Derio-Bilbao, Spain.
  • Zamyatina A; Ikerbasque, Basque Foundation for Science, 48009 Bilbao, Spain.
  • Molinaro A; Facultativo en plantilla (Research Faculty), Instituto de Investigación Marqués de Valdecilla (IDIVAL), 39011 Santander, Spain.
  • Rosano C; Faculty of Pharmaceutical Sciences, University of Iceland, 107 Reykjavik, Iceland.
  • Jakopin Z; Department of Pharmacy, College of Medicine, University of Malawi, Blantyre 3, Malawi.
  • Gursel I; Department of Chemistry, University of Natural Resources and Life Sciences, 1190 Vienna, Austria.
  • McClean S; Department of Chemical Sciences, University of Napoli Federico II, Complesso Universitario Monte Santangelo, I-80126 Napoli, Italy.
Pharmaceutics ; 13(4)2021 Apr 06.
Article in English | MEDLINE | ID: covidwho-1238931
ABSTRACT
Vaccines are the most effective medical intervention due to their continual success in preventing infections and improving mortality worldwide. Early vaccines were developed empirically however, rational design of vaccines can allow us to optimise their efficacy, by tailoring the immune response. Establishing the immune correlates of protection greatly informs the rational design of vaccines. This facilitates the selection of the best vaccine antigens and the most appropriate vaccine adjuvant to generate optimal memory immune T cell and B cell responses. This review outlines the range of vaccine types that are currently authorised and those under development. We outline the optimal immunological correlates of protection that can be targeted. Finally we review approaches to rational antigen selection and rational vaccine adjuvant design. Harnessing current knowledge on protective immune responses in combination with critical vaccine components is imperative to the prevention of future life-threatening diseases.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Pharmaceutics13040501

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Pharmaceutics13040501