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The clinical role of host and bacterial-derived extracellular vesicles in pneumonia.
Jung, Anna Lena; Schmeck, Bernd; Wiegand, Marie; Bedenbender, Katrin; Benedikter, Birke J.
  • Jung AL; Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps University Marburg, Marburg, Hesse, Germany. Electronic address: anna.jung@uni-marburg.de.
  • Schmeck B; Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps University Marburg, Marburg, Hesse, Germany; Department of Pulmonary and Critical Care Medicine, University Medical Center Marburg, Universities of Giessen and Marburg Lung Center, Philipps University Marburg, Hes
  • Wiegand M; Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps University Marburg, Marburg, Hesse, Germany. Electronic address: marie.wiegand@uni-marburg.de.
  • Bedenbender K; Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps University Marburg, Marburg, Hesse, Germany. Electronic address: katrin.bedenbender@uni-marburg.de.
  • Benedikter BJ; Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps University Marburg, Marburg, Hesse, Germany; Department of Medical Microbiology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, the Netherlan
Adv Drug Deliv Rev ; 176: 113811, 2021 09.
Article in English | MEDLINE | ID: covidwho-1239473
ABSTRACT
Pneumonia is among the leading causes of morbidity and mortality worldwide. Due to constant evolution of respiratory bacteria and viruses, development of drug resistance and emerging pathogens, it constitutes a considerable health care threat. To enable development of novel strategies to control pneumonia, a better understanding of the complex mechanisms of interaction between host cells and infecting pathogens is vital. Here, we review the roles of host cell and bacterial-derived extracellular vesicles (EVs) in these interactions. We discuss clinical and experimental as well as pathogen-overarching and pathogen-specific evidence for common viral and bacterial elicitors of community- and hospital-acquired pneumonia. Finally, we highlight the potential of EVs for improved management of pneumonia patients and discuss the translational steps to be taken before they can be safely exploited as novel vaccines, biomarkers, or therapeutics in clinical practice.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pneumonia, Bacterial / Extracellular Vesicles Type of study: Prognostic study Topics: Vaccines Limits: Animals / Humans Language: English Journal: Adv Drug Deliv Rev Journal subject: Pharmacology / Drug Therapy Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pneumonia, Bacterial / Extracellular Vesicles Type of study: Prognostic study Topics: Vaccines Limits: Animals / Humans Language: English Journal: Adv Drug Deliv Rev Journal subject: Pharmacology / Drug Therapy Year: 2021 Document Type: Article