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Comparison of the immune response following subcutaneous versus intranasal modified-live virus booster vaccination against bovine respiratory disease in pre-weaning beef calves that had received primary vaccination by the intranasal route.
Palomares, Roberto A; Bittar, João H J; Woolums, Amelia R; Hoyos-Jaramillo, Alejandro; Hurley, David J; Saliki, Jeremiah T; Ferrer, Maria S; Bullington, Anna C; Rodriguez, Adriana; Murray, Tyler; Thoresen, Merrilee; Jones, Katie; Stoskute, Agne.
  • Palomares RA; Group for Reproduction in Animals, Vaccinology and Infectious Diseases (GRAVID™), College of Veterinary Medicine, University of Georgia, Athens, GA 30602-2771, United States; Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, United States
  • Bittar JHJ; Group for Reproduction in Animals, Vaccinology and Infectious Diseases (GRAVID™), College of Veterinary Medicine, University of Georgia, Athens, GA 30602-2771, United States; Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32
  • Woolums AR; Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, United States.
  • Hoyos-Jaramillo A; Group for Reproduction in Animals, Vaccinology and Infectious Diseases (GRAVID™), College of Veterinary Medicine, University of Georgia, Athens, GA 30602-2771, United States; Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, United States
  • Hurley DJ; Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, United States; Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602-2771, United States.
  • Saliki JT; Oklahoma Animal Disease Diagnostic Laboratory, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, United States.
  • Ferrer MS; Group for Reproduction in Animals, Vaccinology and Infectious Diseases (GRAVID™), College of Veterinary Medicine, University of Georgia, Athens, GA 30602-2771, United States; Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602-2771, Unit
  • Bullington AC; Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602-2771, United States.
  • Rodriguez A; Group for Reproduction in Animals, Vaccinology and Infectious Diseases (GRAVID™), College of Veterinary Medicine, University of Georgia, Athens, GA 30602-2771, United States; Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, United States
  • Murray T; Department of Animal and Dairy Sciences, College of Agriculture and Environmental Sciences, University of Georgia, Athens, GA 30602-2771, United States.
  • Thoresen M; Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, United States.
  • Jones K; Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, United States.
  • Stoskute A; Group for Reproduction in Animals, Vaccinology and Infectious Diseases (GRAVID™), College of Veterinary Medicine, University of Georgia, Athens, GA 30602-2771, United States.
Vet Immunol Immunopathol ; 237: 110254, 2021 Jul.
Article in English | MEDLINE | ID: covidwho-1239778
Semantic information from SemMedBD (by NLM)
1. Vaccine ASSOCIATED_WITH C0036310
Subject
Vaccine
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ASSOCIATED_WITH
Object
C0036310
2. Secondary Immunization AFFECTS Immune response
Subject
Secondary Immunization
Predicate
AFFECTS
Object
Immune response
3. Respiratory viruses COEXISTS_WITH Scheuermann\'s Disease
Subject
Respiratory viruses
Predicate
COEXISTS_WITH
Object
Scheuermann\'s Disease
4. Mucous Membrane LOCATION_OF Bovine herpesvirus 1
Subject
Mucous Membrane
Predicate
LOCATION_OF
Object
Bovine herpesvirus 1
5. Antibody titer measurement USES Serum Neutralization
Subject
Antibody titer measurement
Predicate
USES
Object
Serum Neutralization
6. Antibody titer measurement DIAGNOSES Nasal secretions
Subject
Antibody titer measurement
Predicate
DIAGNOSES
Object
Nasal secretions
7. cytokine compared_with immunoglobulin
Subject
cytokine
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compared_with
Object
immunoglobulin
8. Antibody titer measurement DIAGNOSES Scheuermann\'s Disease
Subject
Antibody titer measurement
Predicate
DIAGNOSES
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Scheuermann\'s Disease
9. Vaccine PART_OF C0042776
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Vaccine
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PART_OF
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C0042776
10. Primary Immunologic Sensitization USES Vaccine
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Primary Immunologic Sensitization
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USES
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Vaccine
11. immunoglobulin TREATS C4747995
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immunoglobulin
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TREATS
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C4747995
12. Specific antibody compared_with Secondary Immunization
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Specific antibody
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compared_with
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Secondary Immunization
13. Vaccines, Attenuated ASSOCIATED_WITH Scheuermann's Disease
Subject
Vaccines, Attenuated
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ASSOCIATED_WITH
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Scheuermann's Disease
14. Secondary Immunization AFFECTS Immune response
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Secondary Immunization
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AFFECTS
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Immune response
15. Respiratory viruses COEXISTS_WITH Scheuermann's Disease
Subject
Respiratory viruses
Predicate
COEXISTS_WITH
Object
Scheuermann's Disease
16. Mucous Membrane LOCATION_OF Bovine herpesvirus 1
Subject
Mucous Membrane
Predicate
LOCATION_OF
Object
Bovine herpesvirus 1
17. Antibody titer measurement USES Serum Neutralization
Subject
Antibody titer measurement
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USES
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Serum Neutralization
18. Antibody titer measurement DIAGNOSES Nasal secretions
Subject
Antibody titer measurement
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DIAGNOSES
Object
Nasal secretions
19. cytokine compared_with immunoglobulin A, human
Subject
cytokine
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compared_with
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immunoglobulin A, human
20. Antibody titer measurement DIAGNOSES Scheuermann's Disease
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Antibody titer measurement
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DIAGNOSES
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Scheuermann's Disease
21. Vaccines, Attenuated PART_OF Virus
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Vaccines, Attenuated
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PART_OF
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Virus
22. Primary Immunologic Sensitization USES Vaccines, Attenuated
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USES
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Vaccines, Attenuated
23. immunoglobulin A, human TREATS Nasal secretions
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immunoglobulin A, human
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TREATS
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Nasal secretions
24. Specific antibody compared_with Secondary Immunization
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Specific antibody
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compared_with
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Secondary Immunization
ABSTRACT
This study was performed to elucidate whether the route of booster vaccination affects the immune response against respiratory vaccine viruses in pre-weaning beef calves that receive primary intranasal (IN) vaccination during the first month of life. The objective was to compare the serum neutralizing antibody (SNA) titers to BHV1, BRSV, and BPI3V, cytokine mRNA expression and mucosal BHV1- and BRSV-specific IgA in nasal secretions following administration of IN or subcutaneous (SC) modified-live virus (MLV) booster vaccines 60 days after primary IN vaccination in young beef calves. Twenty-one beef calves were administered 2 mL of an IN MLV vaccine containing BHV1, BRSV, and BPI3V (Inforce3®) between one and five weeks of age. Sixty days after primary vaccination, calves were randomly assigned to one of two groups IN-MLV (n = 11) Calves received 2 mL of the same IN MLV vaccine used for primary vaccination and 2 mL of a SC MLV vaccine containing BVDV1 & 2 (Bovi- Shield GOLD® BVD). SC-MLV (n = 10) Calves were administered 2 mL of a MLV vaccine containing, BHV1, BRSV, BPI3V, and BVDV1 & 2 (Bovi-Shield GOLD® 5). Blood and nasal secretion samples were collected on days -61 (primary vaccination), -28, -14, 0 (booster vaccination), 14, 21, 28, 42 and 60 for determination of SNA titers, cytokine gene expression analysis and nasal virus-specific IgA concentrations. Statistical analysis was performed using a repeated measures analysis through PROC GLIMMIX of SAS®. Booster vaccination by neither IN nor SC routes induced a significant increase in SNA titers against BHV1, BRSV, and BPI3V. Subcutaneous booster vaccination induced significantly greater BRSV-specific SNA titers (on day 42) and IgA concentration in nasal secretions (on days 21 and 42) compared to calves receiving IN booster vaccination. Both IN and SC booster vaccination were able to stimulate the production of BHV1-specific IgA in nasal secretions. In summary, booster vaccination of young beef calves using either SC or IN route two months after IN MLV primary vaccination resulted in comparable SNA titers, cytokine gene expression profile and virus-specific IgA concentration in nasal secretions. Only a few differences in the systemic and mucosal immune response against BHV1 and BRSV were observed. Subcutaneous booster vaccination induced significantly greater BRSV-specific SNA and secretory IgA titers compared to IN booster vaccination.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Cattle Diseases / Respiratory Syncytial Virus, Bovine / Respiratory Syncytial Virus Vaccines Type of study: Experimental Studies / Randomized controlled trials Topics: Vaccines Limits: Animals Language: English Journal: Vet Immunol Immunopathol Year: 2021 Document Type: Article Affiliation country: J.vetimm.2021.110254

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cattle Diseases / Respiratory Syncytial Virus, Bovine / Respiratory Syncytial Virus Vaccines Type of study: Experimental Studies / Randomized controlled trials Topics: Vaccines Limits: Animals Language: English Journal: Vet Immunol Immunopathol Year: 2021 Document Type: Article Affiliation country: J.vetimm.2021.110254