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Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are features of alpacas resolving MERS-CoV infection.
Te, Nigeer; Rodon, Jordi; Ballester, Maria; Pérez, Mónica; Pailler-García, Lola; Segalés, Joaquim; Vergara-Alert, Júlia; Bensaid, Albert.
  • Te N; IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, Cerdanyola del Vallès, Spain.
  • Rodon J; IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, Cerdanyola del Vallès, Spain.
  • Ballester M; Animal Breeding and Genetics Program, Institute for Research and Technology in Food and Agriculture (IRTA), Caldes de Montbui, Spain.
  • Pérez M; IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, Cerdanyola del Vallès, Spain.
  • Pailler-García L; IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, Cerdanyola del Vallès, Spain.
  • Segalés J; UAB, CReSA (IRTA-UAB), Campus de la UAB, Cerdanyola del Vallès, Spain.
  • Vergara-Alert J; Departament de Sanitat i Anatomia Animals, Facultat de Veterinaria, UAB, Cerdanyola del Vallès, Spain.
  • Bensaid A; IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, Cerdanyola del Vallès, Spain.
PLoS Pathog ; 17(5): e1009229, 2021 05.
Article in English | MEDLINE | ID: covidwho-1239922
Semantic information from SemMedBD (by NLM)
1. Nasal Epithelium PRODUCES Interferons
Subject
Nasal Epithelium
Predicate
PRODUCES
Object
Interferons
2. Middle East Respiratory Syndrome Coronavirus CAUSES Disease
Subject
Middle East Respiratory Syndrome Coronavirus
Predicate
CAUSES
Object
Disease
3. Disease PROCESS_OF Homo sapiens
Subject
Disease
Predicate
PROCESS_OF
Object
Homo sapiens
4. Immune response gene LOCATION_OF Transcriptio
Subject
Immune response gene
Predicate
LOCATION_OF
Object
Transcriptio
5. Structure of mucous membrane of nose LOCATION_OF Interferons
Subject
Structure of mucous membrane of nose
Predicate
LOCATION_OF
Object
Interferons
6. Structure of mucous membrane of nose PART_OF Vicugna pacos
Subject
Structure of mucous membrane of nose
Predicate
PART_OF
Object
Vicugna pacos
7. Genes AUGMENTS Entire respiratory tract
Subject
Genes
Predicate
AUGMENTS
Object
Entire respiratory tract
8. interleukin-10|IL10 INTERACTS_WITH NF-kappa B
Subject
interleukin-10|IL10
Predicate
INTERACTS_WITH
Object
NF-kappa B
9. chemokine LOCATION_OF Transcriptio
Subject
chemokine
Predicate
LOCATION_OF
Object
Transcriptio
10. Lung LOCATION_OF Interferons
Subject
Lung
Predicate
LOCATION_OF
Object
Interferons
11. Inflammatory Response AFFECTS Virus
Subject
Inflammatory Response
Predicate
AFFECTS
Object
Virus
12. Nasal Epithelium PRODUCES Interferons
Subject
Nasal Epithelium
Predicate
PRODUCES
Object
Interferons
13. Middle East Respiratory Syndrome Coronavirus CAUSES Disease
Subject
Middle East Respiratory Syndrome Coronavirus
Predicate
CAUSES
Object
Disease
14. Disease PROCESS_OF Homo sapiens
Subject
Disease
Predicate
PROCESS_OF
Object
Homo sapiens
15. Immune response gene LOCATION_OF Transcription, Genetic
Subject
Immune response gene
Predicate
LOCATION_OF
Object
Transcription, Genetic
16. Structure of mucous membrane of nose LOCATION_OF Interferons
Subject
Structure of mucous membrane of nose
Predicate
LOCATION_OF
Object
Interferons
17. Structure of mucous membrane of nose PART_OF Vicugna pacos
Subject
Structure of mucous membrane of nose
Predicate
PART_OF
Object
Vicugna pacos
18. Genes AUGMENTS Entire respiratory tract
Subject
Genes
Predicate
AUGMENTS
Object
Entire respiratory tract
19. interleukin-10|IL10 INTERACTS_WITH NF-kappa B
Subject
interleukin-10|IL10
Predicate
INTERACTS_WITH
Object
NF-kappa B
20. chemokine LOCATION_OF Transcription, Genetic
Subject
chemokine
Predicate
LOCATION_OF
Object
Transcription, Genetic
21. Lung LOCATION_OF Interferons
Subject
Lung
Predicate
LOCATION_OF
Object
Interferons
22. Inflammatory Response AFFECTS Virus
Subject
Inflammatory Response
Predicate
AFFECTS
Object
Virus
ABSTRACT
While MERS-CoV (Middle East respiratory syndrome Coronavirus) provokes a lethal disease in humans, camelids, the main virus reservoir, are asymptomatic carriers, suggesting a crucial role for innate immune responses in controlling the infection. Experimentally infected camelids clear infectious virus within one week and mount an effective adaptive immune response. Here, transcription of immune response genes was monitored in the respiratory tract of MERS-CoV infected alpacas. Concomitant to the peak of infection, occurring at 2 days post inoculation (dpi), type I and III interferons (IFNs) were maximally transcribed only in the nasal mucosa of alpacas, while interferon stimulated genes (ISGs) were induced along the whole respiratory tract. Simultaneous to mild focal infiltration of leukocytes in nasal mucosa and submucosa, upregulation of the anti-inflammatory cytokine IL10 and dampened transcription of pro-inflammatory genes under NF-κB control were observed. In the lung, early (1 dpi) transcription of chemokines (CCL2 and CCL3) correlated with a transient accumulation of mainly mononuclear leukocytes. A tight regulation of IFNs in lungs with expression of ISGs and controlled inflammatory responses, might contribute to virus clearance without causing tissue damage. Thus, the nasal mucosa, the main target of MERS-CoV in camelids, seems central in driving an efficient innate immune response based on triggering ISGs as well as the dual anti-inflammatory effects of type III IFNs and IL10.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Camelids, New World / Interferon Type I / Interferons / Coronavirus Infections / Middle East Respiratory Syndrome Coronavirus Language: English Journal: PLoS Pathog Year: 2021 Document Type: Article Affiliation country: Journal.ppat.1009229

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Camelids, New World / Interferon Type I / Interferons / Coronavirus Infections / Middle East Respiratory Syndrome Coronavirus Language: English Journal: PLoS Pathog Year: 2021 Document Type: Article Affiliation country: Journal.ppat.1009229