Is Cancer an Independent Risk Factor for Fatal Outcomes of Coronavirus Disease 2019 Patients?
Arch Med Res
; 52(7): 755-760, 2021 10.
Article
in English
| MEDLINE | ID: covidwho-1240192
ABSTRACT
BACKGROUND:
Coronavirus disease 2019 (COVID-19), caused by a novel virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought new challenges for global health systems.OBJECTIVE:
The objective of this study was to investigate whether pre-diagnosed cancer was an independent risk factor for fatal outcomes of coronavirus disease 2019 (COVID-19) patients.METHOD:
A comprehensive search was conducted in major databases of PubMed, Web of Science, and EMBASE to identify all published full-text studies as of January 20, 2021. Inter-study heterogeneity was assessed using Cochran's Q-statistic and I² test. A meta-analysis of random- or fixed-effects model was used to estimate the effect size. Publication bias, sensitivity analysis and subgroup analysis were also carried out.RESULTS:
The confounders-adjusted pooled effects (pooled odds ratio [OR]â¯=â¯1.47, 95% confidence interval [CI] 1.31-1.65; pooled hazard ratio [HR]â¯=â¯1.37, 95% CI 1.21-1.54) indicated that COVID-19 patients with pre-diagnosed cancer were more likely to progress to fatal outcomes based on 96 articles with 6,518,992 COVID-19 patients. Further subgroup analyses by age, sample size, the proportion of males, region, study design and quality rating exhibited consistent findings with the overall effect size.CONCLUSION:
Our analysis provides the objective findings based on the adjusted effect estimates that pre-diagnosed cancer is an independent risk factor for fatal outcome of COVID-19 patients. During the current COVID-19 pandemic, health workers should pay particular attention to cancer care for cancer patients and should prioritize cancer patients for vaccination.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Neoplasms
Type of study:
Observational study
/
Prognostic study
/
Randomized controlled trials
/
Reviews
Topics:
Vaccines
Limits:
Humans
/
Male
Language:
English
Journal:
Arch Med Res
Journal subject:
Medicine
Year:
2021
Document Type:
Article
Affiliation country:
J.arcmed.2021.05.003
Similar
MEDLINE
...
LILACS
LIS