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Is Cancer an Independent Risk Factor for Fatal Outcomes of Coronavirus Disease 2019 Patients?
Xu, Jie; Xiao, Wenwei; Shi, Li; Wang, Yadong; Yang, Haiyan.
  • Xu J; Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, China.
  • Xiao W; Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, China.
  • Shi L; Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, China.
  • Wang Y; Department of Toxicology, Henan Center for Disease Control and Prevention, Zhengzhou, China.
  • Yang H; Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, China. Electronic address: yhy@zzu.edu.cn.
Arch Med Res ; 52(7): 755-760, 2021 10.
Article in English | MEDLINE | ID: covidwho-1240192
ABSTRACT

BACKGROUND:

Coronavirus disease 2019 (COVID-19), caused by a novel virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought new challenges for global health systems.

OBJECTIVE:

The objective of this study was to investigate whether pre-diagnosed cancer was an independent risk factor for fatal outcomes of coronavirus disease 2019 (COVID-19) patients.

METHOD:

A comprehensive search was conducted in major databases of PubMed, Web of Science, and EMBASE to identify all published full-text studies as of January 20, 2021. Inter-study heterogeneity was assessed using Cochran's Q-statistic and I² test. A meta-analysis of random- or fixed-effects model was used to estimate the effect size. Publication bias, sensitivity analysis and subgroup analysis were also carried out.

RESULTS:

The confounders-adjusted pooled effects (pooled odds ratio [OR] = 1.47, 95% confidence interval [CI] 1.31-1.65; pooled hazard ratio [HR] = 1.37, 95% CI 1.21-1.54) indicated that COVID-19 patients with pre-diagnosed cancer were more likely to progress to fatal outcomes based on 96 articles with 6,518,992 COVID-19 patients. Further subgroup analyses by age, sample size, the proportion of males, region, study design and quality rating exhibited consistent findings with the overall effect size.

CONCLUSION:

Our analysis provides the objective findings based on the adjusted effect estimates that pre-diagnosed cancer is an independent risk factor for fatal outcome of COVID-19 patients. During the current COVID-19 pandemic, health workers should pay particular attention to cancer care for cancer patients and should prioritize cancer patients for vaccination.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Neoplasms Type of study: Observational study / Prognostic study / Randomized controlled trials / Reviews Topics: Vaccines Limits: Humans / Male Language: English Journal: Arch Med Res Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: J.arcmed.2021.05.003

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Neoplasms Type of study: Observational study / Prognostic study / Randomized controlled trials / Reviews Topics: Vaccines Limits: Humans / Male Language: English Journal: Arch Med Res Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: J.arcmed.2021.05.003