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Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease.
Bickler, Stephen W; Cauvi, David M; Fisch, Kathleen M; Prieto, James M; Sykes, Alicia G; Thangarajah, Hariharan; Lazar, David A; Ignacio, Romeo C; Gerstmann, Dale R; Ryan, Allen F; Bickler, Philip E; De Maio, Antonio.
  • Bickler SW; Rady Children's Hospital, Rady Children's Hospital, University of California San Diego, 3030 Children's Way, San Diego, CA, 92123, USA. sbickler@health.ucsd.edu.
  • Cauvi DM; Department of Surgery, University of California San Diego, La Jolla, CA, USA. sbickler@health.ucsd.edu.
  • Fisch KM; Center for Investigations of Health and Education Disparities, University of California San Diego, La Jolla, CA, USA. sbickler@health.ucsd.edu.
  • Prieto JM; Department of Surgery, University of California San Diego, La Jolla, CA, USA.
  • Sykes AG; Center for Investigations of Health and Education Disparities, University of California San Diego, La Jolla, CA, USA.
  • Thangarajah H; Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, CA, USA.
  • Lazar DA; Rady Children's Hospital, Rady Children's Hospital, University of California San Diego, 3030 Children's Way, San Diego, CA, 92123, USA.
  • Ignacio RC; Naval Medical Center San Diego, San Diego, CA, USA.
  • Gerstmann DR; Rady Children's Hospital, Rady Children's Hospital, University of California San Diego, 3030 Children's Way, San Diego, CA, 92123, USA.
  • Ryan AF; Naval Medical Center San Diego, San Diego, CA, USA.
  • Bickler PE; Rady Children's Hospital, Rady Children's Hospital, University of California San Diego, 3030 Children's Way, San Diego, CA, 92123, USA.
  • De Maio A; Department of Surgery, University of California San Diego, La Jolla, CA, USA.
BMC Med Genomics ; 14(1): 138, 2021 05 24.
Article in English | MEDLINE | ID: covidwho-1241103
ABSTRACT

BACKGROUND:

Older aged adults and those with pre-existing conditions are at highest risk for severe COVID-19 associated outcomes.

METHODS:

Using a large dataset of genome-wide RNA-seq profiles derived from human dermal fibroblasts (GSE113957) we investigated whether age affects the expression of pattern recognition receptor (PRR) genes and ACE2, the receptor for SARS-CoV-2.

RESULTS:

Extremes of age are associated with increased expression of selected PRR genes, ACE2 and four genes that encode proteins that have been shown to interact with SAR2-CoV-2 proteins.

CONCLUSIONS:

Assessment of PRR expression might provide a strategy for stratifying the risk of severe COVID-19 disease at both the individual and population levels.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Virus / Gene Expression Regulation / Peptidyl-Dipeptidase A / Receptors, Pattern Recognition / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Child / Humans / Middle aged / Young adult Language: English Journal: BMC Med Genomics Journal subject: Genetics, Medical Year: 2021 Document Type: Article Affiliation country: S12920-021-00970-7

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Virus / Gene Expression Regulation / Peptidyl-Dipeptidase A / Receptors, Pattern Recognition / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Child / Humans / Middle aged / Young adult Language: English Journal: BMC Med Genomics Journal subject: Genetics, Medical Year: 2021 Document Type: Article Affiliation country: S12920-021-00970-7