Phytotherapy for treatment of cytokine storm in COVID-19.
Front Biosci (Landmark Ed)
; 26(5): 51-75, 2021 04 30.
Article
in English
| MEDLINE | ID: covidwho-1241385
ABSTRACT
In 2020, a novel strain of coronavirus (COVID-19) has led to a significant morbidity and mortality worldwide. As of the date of this writing, a total of 116 M cases has been diagnosed worldwide leading to 2.5 M deaths. The number of mortalities is directly correlated with the rise of innate immune cells (especially macrophages) in the lungs that secrete inflammatory cytokines (IL-1ß and IL-6) leading to the development of "Cytokine Storm Syndrome" (CSS), multi-organ-failure and death. Given that currently the treatment of this condition is rare and release of effective vaccine might be months away, here, we review the plants and their pharmacologically active-compounds as potential phytopharmaceuticals for the virus induced inflammatory response. Experimental validation of the effectiveness of these natural compounds to prevent or reduce the cytokine storm might be beneficial as an adjunct treatment of SARS-CoV-2.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Plants, Medicinal
/
Plant Extracts
/
Cytokine Release Syndrome
/
SARS-CoV-2
/
COVID-19 Drug Treatment
/
Phytotherapy
Type of study:
Observational study
/
Prognostic study
Topics:
Traditional medicine
/
Vaccines
Limits:
Humans
Language:
English
Journal:
Front Biosci (Landmark Ed)
Year:
2021
Document Type:
Article
Affiliation country:
4924
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