Your browser doesn't support javascript.
Phytotherapy for treatment of cytokine storm in COVID-19.
Sapra, Leena; Bhardwaj, Asha; Azam, Zaffar; Madhry, Deekhsha; Verma, Bhupendra; Rathore, Sumit; Srivastava, Rupesh K.
  • Sapra L; Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), 110029 New Delhi, India.
  • Bhardwaj A; Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), 110029 New Delhi, India.
  • Azam Z; Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), 110029 New Delhi, India.
  • Madhry D; Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), 110029 New Delhi, India.
  • Verma B; Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), 110029 New Delhi, India.
  • Rathore S; Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), 110029 New Delhi, India.
  • Srivastava RK; Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), 110029 New Delhi, India.
Front Biosci (Landmark Ed) ; 26(5): 51-75, 2021 04 30.
Article in English | MEDLINE | ID: covidwho-1241385
ABSTRACT
In 2020, a novel strain of coronavirus (COVID-19) has led to a significant morbidity and mortality worldwide. As of the date of this writing, a total of 116 M cases has been diagnosed worldwide leading to 2.5 M deaths. The number of mortalities is directly correlated with the rise of innate immune cells (especially macrophages) in the lungs that secrete inflammatory cytokines (IL-1ß and IL-6) leading to the development of "Cytokine Storm Syndrome" (CSS), multi-organ-failure and death. Given that currently the treatment of this condition is rare and release of effective vaccine might be months away, here, we review the plants and their pharmacologically active-compounds as potential phytopharmaceuticals for the virus induced inflammatory response. Experimental validation of the effectiveness of these natural compounds to prevent or reduce the cytokine storm might be beneficial as an adjunct treatment of SARS-CoV-2.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Plants, Medicinal / Plant Extracts / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 Drug Treatment / Phytotherapy Type of study: Observational study / Prognostic study Topics: Traditional medicine / Vaccines Limits: Humans Language: English Journal: Front Biosci (Landmark Ed) Year: 2021 Document Type: Article Affiliation country: 4924

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Plants, Medicinal / Plant Extracts / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 Drug Treatment / Phytotherapy Type of study: Observational study / Prognostic study Topics: Traditional medicine / Vaccines Limits: Humans Language: English Journal: Front Biosci (Landmark Ed) Year: 2021 Document Type: Article Affiliation country: 4924