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The Intersection of Parkinson's Disease, Viral Infections, and COVID-19.
Rosen, Benjamin; Kurtishi, Alberim; Vazquez-Jimenez, Gonzalo R; Møller, Simon Geir.
  • Rosen B; Department of Biological Sciences, St. John's University, New York, NY, 11439, USA.
  • Kurtishi A; Department of Biological Sciences, St. John's University, New York, NY, 11439, USA.
  • Vazquez-Jimenez GR; Department of Biological Sciences, St. John's University, New York, NY, 11439, USA.
  • Møller SG; Department of Biological Sciences, St. John's University, New York, NY, 11439, USA. mollers@stjohns.edu.
Mol Neurobiol ; 58(9): 4477-4486, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1241710
ABSTRACT
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of human COVID-19, not only causes flu-like symptoms and gut microbiome complications but a large number of infected individuals also experience a host of neurological symptoms including loss of smell and taste, seizures, difficulty concentrating, decreased alertness, and brain inflammation. Although SARS-CoV-2 infections are not more prevalent in Parkinson's disease patients, a higher mortality rate has been reported not only associated with older age and longer disease duration, but also through several mechanisms, such as interactions with the brain dopaminergic system and through systemic inflammatory responses. Indeed, a number of the neurological symptoms seen in COVID-19 patients, as well as the alterations in the gut microbiome, are also prevalent in patients with Parkinson's disease. Furthermore, biochemical pathways such as oxidative stress, inflammation, and protein aggregation have shared commonalities between Parkinson's disease and COVID-19 disease progression. In this review, we describe and compare the numerous similarities and intersections between neurodegeneration in Parkinson's disease and RNA viral infections, emphasizing the current SARS-CoV-2 global health crisis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Parkinson Disease / Gastrointestinal Microbiome / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Aged / Humans Language: English Journal: Mol Neurobiol Journal subject: Molecular Biology / Neurology Year: 2021 Document Type: Article Affiliation country: S12035-021-02408-8

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Parkinson Disease / Gastrointestinal Microbiome / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Aged / Humans Language: English Journal: Mol Neurobiol Journal subject: Molecular Biology / Neurology Year: 2021 Document Type: Article Affiliation country: S12035-021-02408-8