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Patients with COVID-19: in the dark-NETs of neutrophils.
Ackermann, Maximilian; Anders, Hans-Joachim; Bilyy, Rostyslav; Bowlin, Gary L; Daniel, Christoph; De Lorenzo, Rebecca; Egeblad, Mikala; Henneck, Timo; Hidalgo, Andrés; Hoffmann, Markus; Hohberger, Bettina; Kanthi, Yogendra; Kaplan, Mariana J; Knight, Jason S; Knopf, Jasmin; Kolaczkowska, Elzbieta; Kubes, Paul; Leppkes, Moritz; Mahajan, Aparna; Manfredi, Angelo A; Maueröder, Christian; Maugeri, Norma; Mitroulis, Ioannis; Muñoz, Luis E; Narasaraju, Teluguakula; Naschberger, Elisabeth; Neeli, Indira; Ng, Lai Guan; Radic, Marko Z; Ritis, Konstantinos; Rovere-Querini, Patrizia; Schapher, Mirco; Schauer, Christine; Simon, Hans-Uwe; Singh, Jeeshan; Skendros, Panagiotis; Stark, Konstantin; Stürzl, Michael; van der Vlag, Johan; Vandenabeele, Peter; Vitkov, Ljubomir; von Köckritz-Blickwede, Maren; Yanginlar, Cansu; Yousefi, Shida; Zarbock, Alexander; Schett, Georg; Herrmann, Martin.
  • Ackermann M; Institute of Pathology and Molecular Pathology, Helios University Clinic Wuppertal, University of Witten/Herdecke, Wuppertal, Germany.
  • Anders HJ; Institute of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
  • Bilyy R; Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.
  • Bowlin GL; Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
  • Daniel C; Department of Biomedical Engineering, University of Memphis, Memphis, TN, USA.
  • De Lorenzo R; Department of Nephropathology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg, Erlangen, Germany.
  • Egeblad M; Università Vita-Salute San Raffaele & IRCCS San Raffaele Scientific Institute, Milano, Italy.
  • Henneck T; Cold Spring Harbor Laboratory Cancer Center, Cold Spring Harbor, NY, USA.
  • Hidalgo A; Institute for Biochemistry and Research Center for Emerging Infections and Zonoses, University of Veterinary Medicine Hannover, Hannover, Germany.
  • Hoffmann M; Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
  • Hohberger B; Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Kanthi Y; Deutsches Zentrum für Immuntherapie (DZI), Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Kaplan MJ; Department of Ophthalmology, University of Erlangen-Nürnberg, Erlangen, Germany.
  • Knight JS; Division of Intramural Research, National Heart, Lung and Blood Institute, Bethesda, MD, USA.
  • Knopf J; Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
  • Kolaczkowska E; Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Kubes P; Division of Rheumatology, University of Michigan, Ann Arbor, MI, USA.
  • Leppkes M; Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Mahajan A; Deutsches Zentrum für Immuntherapie (DZI), Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Manfredi AA; Department of Experimental Hematology, Institute of Zoology and Biomedical Research, Jagiellonian University, Krakow, Poland.
  • Maueröder C; Snyder Institute for Chronic Disease, University of Calgary, Alberta, Canada.
  • Maugeri N; Deutsches Zentrum für Immuntherapie (DZI), Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Mitroulis I; Department of Internal Medicine 1, Friedrich Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Muñoz LE; Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Narasaraju T; Deutsches Zentrum für Immuntherapie (DZI), Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Naschberger E; Università Vita-Salute San Raffaele & IRCCS San Raffaele Scientific Institute, Milano, Italy.
  • Neeli I; Cell Clearance in Health and Disease Lab, VIB-UGent Center for Inflammation Research (IRC), Ghent, Belgium.
  • Ng LG; Department of Biomedical Molecular Biology (DBMB), Ghent University, Ghent, Belgium.
  • Radic MZ; Università Vita-Salute San Raffaele & IRCCS San Raffaele Scientific Institute, Milano, Italy.
  • Ritis K; First Department of Internal Medicine, Department of Medicine, University Hospital of Alexandroupolis, and Laboratory of Molecular Hematology, Democritus University of Thrace, Alexandroupolis, Greece.
  • Rovere-Querini P; Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Schapher M; Deutsches Zentrum für Immuntherapie (DZI), Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Schauer C; School of Health Care Administration, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA.
  • Simon HU; Division of Molecular and Experimental Surgery, Translational Research Center, Department of Surgery, University Medical Center Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Singh J; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, USA.
  • Skendros P; Singapore Immunology Network (SIgN), A*STAR, Biopolis, Singapore, Singapore.
  • Stark K; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, USA.
  • Stürzl M; First Department of Internal Medicine, Department of Medicine, University Hospital of Alexandroupolis, and Laboratory of Molecular Hematology, Democritus University of Thrace, Alexandroupolis, Greece.
  • van der Vlag J; Università Vita-Salute San Raffaele & IRCCS San Raffaele Scientific Institute, Milano, Italy.
  • Vandenabeele P; Department of Otolaryngology, Friedrich-Alexander-University Erlangen-Nürnberg, Head and Neck Surgery, Universitätsklinikum Erlangen, Erlangen, Germany.
  • Vitkov L; Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
  • von Köckritz-Blickwede M; Deutsches Zentrum für Immuntherapie (DZI), Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Yanginlar C; Institute of Pharmacology, University of Bern, Inselspital, INO-F, Bern, Switzerland.
  • Yousefi S; Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Zarbock A; Deutsches Zentrum für Immuntherapie (DZI), Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Schett G; First Department of Internal Medicine, Department of Medicine, University Hospital of Alexandroupolis, and Laboratory of Molecular Hematology, Democritus University of Thrace, Alexandroupolis, Greece.
  • Herrmann M; Medizinische Klinik I, Klinikum der Ludwig-Maximilians-Universität, Munich, Germany.
Cell Death Differ ; 28(11): 3125-3139, 2021 11.
Article in English | MEDLINE | ID: covidwho-1241944
Semantic information from SemMedBD (by NLM)
1. SPINK5 gene|SPINK5 PART_OF neutrophil
Subject
SPINK5 gene|SPINK5
Predicate
PART_OF
Object
neutrophil
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. COVID-19 CAUSES Cessation of life
Subject
COVID-19
Predicate
CAUSES
Object
Cessation of life
4. Therapeutic procedure PREVENTS Single organ dysfunction
Subject
Therapeutic procedure
Predicate
PREVENTS
Object
Single organ dysfunction
5. Single organ dysfunction PROCESS_OF Patients
Subject
Single organ dysfunction
Predicate
PROCESS_OF
Object
Patients
6. SPINK5 gene|SPINK5 ASSOCIATED_WITH Tissue injury
Subject
SPINK5 gene|SPINK5
Predicate
ASSOCIATED_WITH
Object
Tissue injury
7. SPINK5 gene|SPINK5 PART_OF neutrophil
Subject
SPINK5 gene|SPINK5
Predicate
PART_OF
Object
neutrophil
8. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
9. COVID-19 CAUSES Cessation of life
Subject
COVID-19
Predicate
CAUSES
Object
Cessation of life
10. Therapeutic procedure PREVENTS Single organ dysfunction
Subject
Therapeutic procedure
Predicate
PREVENTS
Object
Single organ dysfunction
11. Single organ dysfunction PROCESS_OF Patients
Subject
Single organ dysfunction
Predicate
PROCESS_OF
Object
Patients
12. SPINK5 gene|SPINK5 ASSOCIATED_WITH Tissue injury
Subject
SPINK5 gene|SPINK5
Predicate
ASSOCIATED_WITH
Object
Tissue injury
ABSTRACT
SARS-CoV-2 infection poses a major threat to the lungs and multiple other organs, occasionally causing death. Until effective vaccines are developed to curb the pandemic, it is paramount to define the mechanisms and develop protective therapies to prevent organ dysfunction in patients with COVID-19. Individuals that develop severe manifestations have signs of dysregulated innate and adaptive immune responses. Emerging evidence implicates neutrophils and the disbalance between neutrophil extracellular trap (NET) formation and degradation plays a central role in the pathophysiology of inflammation, coagulopathy, organ damage, and immunothrombosis that characterize severe cases of COVID-19. Here, we discuss the evidence supporting a role for NETs in COVID-19 manifestations and present putative mechanisms, by which NETs promote tissue injury and immunothrombosis. We present therapeutic strategies, which have been successful in the treatment of immunο-inflammatory disorders and which target dysregulated NET formation or degradation, as potential approaches that may benefit patients with severe COVID-19.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Extracellular Traps / COVID-19 / Neutrophils Type of study: Etiology study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Cell Death Differ Year: 2021 Document Type: Article Affiliation country: S41418-021-00805-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Extracellular Traps / COVID-19 / Neutrophils Type of study: Etiology study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Cell Death Differ Year: 2021 Document Type: Article Affiliation country: S41418-021-00805-z