Compartmental Model Suggests Importance of Innate Immune Response to COVID-19 Infection in Rhesus Macaques.
Bull Math Biol
; 83(7): 79, 2021 05 26.
Article
in English
| MEDLINE | ID: covidwho-1242816
ABSTRACT
The pandemic outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has quickly spread worldwide, creating a serious health crisis. The virus is primarily associated with flu-like symptoms but can also lead to severe pathologies and death. We here present an ordinary differential equation model of the intrahost immune response to SARS-CoV-2 infection, fitted to experimental data gleaned from rhesus macaques. The model is calibrated to data from a nonlethal infection, but the model can replicate behavior from various lethal scenarios as well. We evaluate the sensitivity of the model to biologically relevant parameters governing the strength and efficacy of the immune response. We also simulate the effect of both anti-inflammatory and antiviral drugs on the host immune response and demonstrate the ability of the model to lessen the severity of a formerly lethal infection with the addition of the appropriately calibrated drug. Our model emphasizes the importance of tight control of the innate immune response for host survival and viral clearance.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Models, Immunological
/
SARS-CoV-2
/
COVID-19
/
Immunity, Innate
/
Macaca mulatta
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Bull Math Biol
Year:
2021
Document Type:
Article
Affiliation country:
S11538-021-00909-0
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