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Characterization of Headache in COVID-19: a Retrospective Multicenter Study.
Dos Anjos de Paula, Rafael César; de Maria Frota Vasconcelos, Thaís; da Costa, Francisco Bruno Santana; de Brito, Lara Albuquerque; Torres, Danielle Mesquita; Moura, Alissa Elen Formiga; Oliveira, Danilo Nunes; de Lima Henn, Guilherme Alves; Rodrigues, Pedro Gustavo Barros; de Sousa Pereira, Isabelle; Braga, Ianna Lacerda Sampaio; Rocha, Felipe Araújo; Frota, Norberto Anízio Ferreira; Carvalho, Fernanda Martins Maia; Pitombeira, Milena Sales; Tavares-Junior, José Wagner Leonel; Montenegro, Raquel Carvalho; Braga-Neto, Pedro; Nóbrega, Paulo Ribeiro; Sobreira-Neto, Manoel Alves.
  • Dos Anjos de Paula RC; Division of Neurology, Department of Clinical Medicine, Universidade Federal Do Ceará, Fortaleza, Brazil.
  • de Maria Frota Vasconcelos T; Division of Neurology, Department of Clinical Medicine, Universidade Federal Do Ceará, Fortaleza, Brazil.
  • da Costa FBS; Division of Neurology, Department of Clinical Medicine, Universidade Federal Do Ceará, Fortaleza, Brazil.
  • de Brito LA; Department of Neurology, Hospital Geral de Fortaleza, Fortaleza, Brazil.
  • Torres DM; Department of Neurology, Hospital Geral de Fortaleza, Fortaleza, Brazil.
  • Moura AEF; Department of Neurology, Hospital Geral de Fortaleza, Fortaleza, Brazil.
  • Oliveira DN; Division of Neurology, Department of Clinical Medicine, Universidade Federal Do Ceará, Fortaleza, Brazil.
  • de Lima Henn GA; Division of Infectious Diseases, Department of Clinical Medicine, Universidade Federal Do Ceará, Fortaleza, Brazil.
  • Rodrigues PGB; Department of Infectious Diseases, Hospital São José de Doenças Infecciosas, Fortaleza, Brazil.
  • de Sousa Pereira I; Division of Neurology, Department of Clinical Medicine, Universidade Federal Do Ceará, Fortaleza, Brazil.
  • Braga ILS; Division of Neurology, Department of Clinical Medicine, Universidade Federal Do Ceará, Fortaleza, Brazil.
  • Rocha FA; Department of Gerontology, Hospital Geral Cesar Cals, Fortaleza, Brazil.
  • Frota NAF; Department of Neurology, Hospital Geral de Fortaleza, Fortaleza, Brazil.
  • Carvalho FMM; Department of Neurology, Hospital Geral de Fortaleza, Fortaleza, Brazil.
  • Pitombeira MS; Universidade de Fortaleza, Fortaleza, Brazil.
  • Tavares-Junior JWL; Department of Neurology, Hospital Geral de Fortaleza, Fortaleza, Brazil.
  • Montenegro RC; Universidade de Fortaleza, Fortaleza, Brazil.
  • Braga-Neto P; Department of Neurology, Hospital Geral de Fortaleza, Fortaleza, Brazil.
  • Nóbrega PR; Division of Neurology, Department of Clinical Medicine, Universidade Federal Do Ceará, Fortaleza, Brazil.
  • Sobreira-Neto MA; Núcleo de Pesquisa E Desenvolvimento de Medicamentos, Universidade Federal Do Ceará, Fortaleza, Brazil.
Mol Neurobiol ; 58(9): 4487-4494, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1242821
Semantic information from SemMedBD (by NLM)
1. Headache ASSOCIATED_WITH COVID-19
Subject
Headache
Predicate
ASSOCIATED_WITH
Object
COVID-19
2. Neurologic Symptoms ASSOCIATED_WITH COVID-19
Subject
Neurologic Symptoms
Predicate
ASSOCIATED_WITH
Object
COVID-19
3. Neurologic Symptoms COEXISTS_WITH 6/5
Subject
Neurologic Symptoms
Predicate
COEXISTS_WITH
Object
6/5
4. Neurologic Symptoms PROCESS_OF Patients
Subject
Neurologic Symptoms
Predicate
PROCESS_OF
Object
Patients
5. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
6. Headache PROCESS_OF Patients
Subject
Headache
Predicate
PROCESS_OF
Object
Patients
7. Headache ASSOCIATED_WITH COVID-19
Subject
Headache
Predicate
ASSOCIATED_WITH
Object
COVID-19
8. Neurologic Symptoms ASSOCIATED_WITH COVID-19
Subject
Neurologic Symptoms
Predicate
ASSOCIATED_WITH
Object
COVID-19
9. Neurologic Symptoms COEXISTS_WITH 6/5
Subject
Neurologic Symptoms
Predicate
COEXISTS_WITH
Object
6/5
10. Neurologic Symptoms PROCESS_OF Patients
Subject
Neurologic Symptoms
Predicate
PROCESS_OF
Object
Patients
11. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
12. Headache PROCESS_OF Patients
Subject
Headache
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
Headache is the most common neurological symptom in COVID-19, reported in 6.5 to 34% of patients. Few studies have analyzed its characteristics, and some of them included cases without laboratory confirmation or reported only critical patients. We aimed to analyze the clinical characteristics of COVID-19 associated headache in laboratory-confirmed cases. We conducted a retrospective evaluation of patients with COVID-19 and neurological symptoms. Patients who reported headache answered an interview about its clinical characteristics. Twenty-four patients with COVID-19 associated headache completed the interview. Mean age of patients was 53.8 (standard deviation-17.44), and 14 out of 24 (58.3%) were male. The majority (75%) had no previous history of headache. Fever was documented in 19 out of the 24 patients (79.1%). Headache was predominantly bifrontal or holocranial, in pressure, during hours, worsening with cough or physical activity. COVID-19 headache tends to appear in the first days of symptoms, be either frontal or holocranial and last for days. The quality of pain in pressure and the worsening with cough or physical activity were reported in most cases. We have not found any characteristic that could differentiate COVID-19 associated headache from other causes of headache, possibly because of its multifactorial mechanism.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Headache Type of study: Controlled clinical trial / Diagnostic study / Etiology study / Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Female / Humans / Male / Young adult Language: English Journal: Mol Neurobiol Journal subject: Molecular Biology / Neurology Year: 2021 Document Type: Article Affiliation country: S12035-021-02430-w

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Headache Type of study: Controlled clinical trial / Diagnostic study / Etiology study / Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Female / Humans / Male / Young adult Language: English Journal: Mol Neurobiol Journal subject: Molecular Biology / Neurology Year: 2021 Document Type: Article Affiliation country: S12035-021-02430-w