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Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection.
Montefusco, Laura; Ben Nasr, Moufida; D'Addio, Francesca; Loretelli, Cristian; Rossi, Antonio; Pastore, Ida; Daniele, Giuseppe; Abdelsalam, Ahmed; Maestroni, Anna; Dell'Acqua, Marco; Ippolito, Elio; Assi, Emma; Usuelli, Vera; Seelam, Andy Joe; Fiorina, Roberta Maria; Chebat, Enrica; Morpurgo, Paola; Lunati, Maria Elena; Bolla, Andrea Mario; Finzi, Giovanna; Abdi, Reza; Bonventre, Joseph V; Rusconi, Stefano; Riva, Agostino; Corradi, Domenico; Santus, Pierachille; Nebuloni, Manuela; Folli, Franco; Zuccotti, Gian Vincenzo; Galli, Massimo; Fiorina, Paolo.
  • Montefusco L; Division of Endocrinology, ASST Fatebenefratelli-Sacco, Milan, Italy.
  • Ben Nasr M; International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.
  • D'Addio F; Nephrology Division, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
  • Loretelli C; International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.
  • Rossi A; International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.
  • Pastore I; Division of Endocrinology, ASST Fatebenefratelli-Sacco, Milan, Italy.
  • Daniele G; Division of Endocrinology, ASST Fatebenefratelli-Sacco, Milan, Italy.
  • Abdelsalam A; Metabolic Diseases, Department of Medicine, University of Pisa, Pisa, Italy.
  • Maestroni A; International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.
  • Dell'Acqua M; International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.
  • Ippolito E; International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.
  • Assi E; Division of Endocrinology, Aziende Socio Sanitarie Territoriali Fatebenefratelli Sacco, Milan, Italy.
  • Usuelli V; International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.
  • Seelam AJ; International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.
  • Fiorina RM; International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.
  • Chebat E; International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.
  • Morpurgo P; International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.
  • Lunati ME; Division of Endocrinology, ASST Fatebenefratelli-Sacco, Milan, Italy.
  • Bolla AM; Division of Endocrinology, ASST Fatebenefratelli-Sacco, Milan, Italy.
  • Finzi G; Division of Endocrinology, ASST Fatebenefratelli-Sacco, Milan, Italy.
  • Abdi R; Division of Endocrinology, ASST Fatebenefratelli-Sacco, Milan, Italy.
  • Bonventre JV; Department of Pathology, University Hospital ASST-Settelaghi, Varese, Italy.
  • Rusconi S; Renal Division and Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Riva A; Renal Division and Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Corradi D; Infectious Diseases Unit, ASST Fatebenefratelli-Sacco, Milan, Italy.
  • Santus P; Infectious Diseases Unit, ASST Fatebenefratelli-Sacco, Milan, Italy.
  • Nebuloni M; Department of Biomedical, Biotechnological and Translational Sciences, Unit of Pathology, University of Parma, Parma, Italy.
  • Folli F; Division of Respiratory Diseases, Ospedale L. Sacco, ASST Fatebenefratelli-Sacco, Milan, Italy.
  • Zuccotti GV; Department of Biomedical and Clinical Sciences, DIBIC, Università di Milano, Milan, Italy.
  • Galli M; Department of Pathology, Papa Giovanni XXIII Hospital, Bergamo, Italy.
  • Fiorina P; Department of Biomedical and Clinical Sciences, Università di Milano, Milan, Italy.
Nat Metab ; 3(6): 774-785, 2021 06.
Article in English | MEDLINE | ID: covidwho-1243313
ABSTRACT
Patients with coronavirus disease 2019 (COVID-19) are reported to have a greater prevalence of hyperglycaemia. Cytokine release as a consequence of severe acute respiratory syndrome coronavirus 2 infection may precipitate the onset of metabolic alterations by affecting glucose homeostasis. Here we describe abnormalities in glycometabolic control, insulin resistance and beta cell function in patients with COVID-19 without any pre-existing history or diagnosis of diabetes, and document glycaemic abnormalities in recovered patients 2 months after onset of disease. In a cohort of 551 patients hospitalized for COVID-19 in Italy, we found that 46% of patients were hyperglycaemic, whereas 27% were normoglycaemic. Using clinical assays and continuous glucose monitoring in a subset of patients, we detected altered glycometabolic control, with insulin resistance and an abnormal cytokine profile, even in normoglycaemic patients. Glycaemic abnormalities can be detected for at least 2 months in patients who recovered from COVID-19. Our data demonstrate that COVID-19 is associated with aberrant glycometabolic control, which can persist even after recovery, suggesting that further investigation of metabolic abnormalities in the context of long COVID is warranted.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Glucose / COVID-19 / Hyperglycemia Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Nat Metab Year: 2021 Document Type: Article Affiliation country: S42255-021-00407-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Glucose / COVID-19 / Hyperglycemia Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Nat Metab Year: 2021 Document Type: Article Affiliation country: S42255-021-00407-6