Chemical probes targeting the kinase CK2: a journey outside the catalytic box.
Org Biomol Chem
; 19(20): 4380-4396, 2021 05 26.
Article
in English
| MEDLINE | ID: covidwho-1243316
ABSTRACT
CK2 is a protein kinase that plays important roles in many physio-pathological cellular processes. As such, the development of chemical probes for CK2 has received increasing attention in the past decade with more than 40 lead compounds developed. In this review, we aim to provide the reader with a comprehensive overview of the chemical probes acting outside the highly-conserved ATP-site developed to date. Such probes belong to different classes of molecules spanning from small molecules to peptides, act with a range of mechanisms of action and some of them present themselves as promising tools to investigate the biology of CK2 and therefore develop therapeutics for many disease areas including cancer and COVID-19.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Molecular Probes
/
Casein Kinase II
Limits:
Animals
/
Humans
Language:
English
Journal:
Org Biomol Chem
Journal subject:
Biochemistry
/
Chemistry
Year:
2021
Document Type:
Article
Affiliation country:
D1ob00257k
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