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Comparison of Acute Kidney Injury in Patients with COVID-19 and Other Respiratory Infections: A Prospective Cohort Study.
Diebold, Matthias; Zimmermann, Tobias; Dickenmann, Michael; Schaub, Stefan; Bassetti, Stefano; Tschudin-Sutter, Sarah; Bingisser, Roland; Heim, Corin; Siegemund, Martin; Osswald, Stefan; Kuster, Gabriela M; Rentsch, Katharina M; Breidthardt, Tobias; Twerenbold, Raphael.
  • Diebold M; Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.
  • Zimmermann T; Department of Intensive Care Medicine, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.
  • Dickenmann M; Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.
  • Schaub S; Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.
  • Bassetti S; Division of Internal Medicine, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.
  • Tschudin-Sutter S; Department of Clinical Research, University of Basel, 4031 Basel, Switzerland.
  • Bingisser R; Division of Infectious Disease & Hospital Epidemiology, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.
  • Heim C; Emergency Department, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.
  • Siegemund M; Emergency Department, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.
  • Osswald S; Department of Intensive Care Medicine, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.
  • Kuster GM; Department of Clinical Research, University of Basel, 4031 Basel, Switzerland.
  • Rentsch KM; Department of Cardiology, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.
  • Breidthardt T; Department of Cardiology, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.
  • Twerenbold R; Department of Laboratory Medicine, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.
J Clin Med ; 10(11)2021 May 25.
Article in English | MEDLINE | ID: covidwho-1244049
Semantic information from SemMedBD (by NLM)
1. Kidney Failur PROCESS_OF C0030705
Subject
Kidney Failur
Predicate
PROCESS_OF
Object
C0030705
2. Respiratory Tract Infections PROCESS_OF Patients
Subject
Respiratory Tract Infections
Predicate
PROCESS_OF
Object
Patients
3. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
4. Symptoms PROCESS_OF Patients
Subject
Symptoms
Predicate
PROCESS_OF
Object
Patients
5. Hospital LOCATION_OF C2603343
Subject
Hospital
Predicate
LOCATION_OF
Object
C2603343
6. Cessation of life ASSOCIATED_WITH Kidney Failur
Subject
Cessation of life
Predicate
ASSOCIATED_WITH
Object
Kidney Failur
7. Swab DIAGNOSES 2019 novel coronavirus
Subject
Swab
Predicate
DIAGNOSES
Object
2019 novel coronavirus
8. High severity PROCESS_OF Patients
Subject
High severity
Predicate
PROCESS_OF
Object
Patients
9. Kidney Failure, Acute PROCESS_OF Patients
Subject
Kidney Failure, Acute
Predicate
PROCESS_OF
Object
Patients
10. Respiratory Tract Infections PROCESS_OF Patients
Subject
Respiratory Tract Infections
Predicate
PROCESS_OF
Object
Patients
11. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
12. Symptoms PROCESS_OF Patients
Subject
Symptoms
Predicate
PROCESS_OF
Object
Patients
13. Hospitals, University LOCATION_OF Study
Subject
Hospitals, University
Predicate
LOCATION_OF
Object
Study
14. Cessation of life ASSOCIATED_WITH Kidney Failure, Acute
Subject
Cessation of life
Predicate
ASSOCIATED_WITH
Object
Kidney Failure, Acute
15. Swab DIAGNOSES 2019 novel coronavirus
Subject
Swab
Predicate
DIAGNOSES
Object
2019 novel coronavirus
16. High severity PROCESS_OF Patients
Subject
High severity
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
Previous studies have indicated an association between coronavirus disease 2019 (COVID-19) and acute kidney injury (AKI) but lacked a control group. The prospective observational COronaVIrus-surviVAl (COVIVA) study performed at the University Hospital, Basel, Switzerland consecutively enrolled patients with symptoms suggestive of COVID-19. We compared patients who tested positive for SARS-CoV-2 with patients who tested negative but with an adjudicated diagnosis of a respiratory tract infection, including pneumonia. The primary outcome measure was death at 30 days, and the secondary outcomes were AKI incidence and a composite endpoint of death, intensive care treatment or rehospitalization at 30 days. Five hundred and seven patients were diagnosed with respiratory tract infections, and of those, 183 (36%) had a positive PCR swab test for SARS-CoV-2. The incidence of AKI was higher in patients with COVID-19 (30% versus 12%, p < 0.001), more severe (KDIGO stage 3, 22% versus 13%, p = 0.009) and more often required renal replacement therapy (4.4% versus 0.93%; p = 0.03). The risk of 30-day mortality and a composite endpoint was higher in patients with COVID-19-associated AKI (adjusted hazard ratio (aHR) mortality 3.98, 95% confidence interval (CI) 1.10-14.46, p = 0.036; composite endpoint aHR 1.84, 95% CI 1.02-3.31, p = 0.042). The mortality risk was attenuated when adjusting for disease severity (aHR 3.60, 95% CI 0.93-13.96, p = 0.062). AKI occurs more frequently and with a higher severity in patients with COVID-19 and is associated with worse outcomes.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Observational study / Risk factors Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10112288

Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Observational study / Risk factors Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10112288