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Noble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2.
Chuong, Christina; DuChane, Christine M; Webb, Emily M; Rai, Pallavi; Marano, Jeffrey M; Bernier, Chad M; Merola, Joseph S; Weger-Lucarelli, James.
  • Chuong C; Department of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD Regional College of Veterinary Medicine, Blacksburg, VA 24061, USA.
  • DuChane CM; Department of Chemistry, Virginia Tech, Blacksburg, VA 24061, USA.
  • Webb EM; Department of Entomology, Virginia Tech, Blacksburg, VA 24061, USA.
  • Rai P; Department of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD Regional College of Veterinary Medicine, Blacksburg, VA 24061, USA.
  • Marano JM; Department of Translational Biology, Medicine, and Health, Virginia Tech, Blacksburg, VA 24061, USA.
  • Bernier CM; Department of Chemistry, Virginia Tech, Blacksburg, VA 24061, USA.
  • Merola JS; Department of Chemistry, Virginia Tech, Blacksburg, VA 24061, USA.
  • Weger-Lucarelli J; Department of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD Regional College of Veterinary Medicine, Blacksburg, VA 24061, USA.
Viruses ; 13(6)2021 05 25.
Article in English | MEDLINE | ID: covidwho-1244147
ABSTRACT
SARS-CoV-2 emerged in 2019 as a devastating viral pathogen with no available preventative or treatment to control what led to the current global pandemic. The continued spread of the virus and increasing death toll necessitate the development of effective antiviral treatments to combat this virus. To this end, we evaluated a new class of organometallic complexes as potential antivirals. Our findings demonstrate that two pentamethylcyclopentadienyl (Cp*) rhodium piano stool complexes, Cp*Rh(1,3-dicyclohexylimidazol-2-ylidene)Cl2 (complex 2) and Cp*Rh(dipivaloylmethanato)Cl (complex 4), have direct virucidal activity against SARS-CoV-2. Subsequent in vitro testing suggests that complex 4 is the more stable and effective complex and demonstrates that both 2 and 4 have low toxicity in Vero E6 and Calu-3 cells. The results presented here highlight the potential application of organometallic complexes as antivirals and support further investigation into their activity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Organometallic Compounds / SARS-CoV-2 Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: V13060980

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Organometallic Compounds / SARS-CoV-2 Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: V13060980