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Effects of a Single Dose of Ivermectin on Viral and Clinical Outcomes in Asymptomatic SARS-CoV-2 Infected Subjects: A Pilot Clinical Trial in Lebanon.
Samaha, Ali A; Mouawia, Hussein; Fawaz, Mirna; Hassan, Hamad; Salami, Ali; Bazzal, Ali Al; Saab, Hamid Bou; Al-Wakeel, Mohamed; Alsaabi, Ahmad; Chouman, Mohamad; Moussawi, Mahmoud Al; Ayoub, Hassan; Raad, Ali; Hajjeh, Ola; Eid, Ali H; Raad, Houssam.
  • Samaha AA; Faculty of Public Health, Lebanese University, Beirut P.O. Box 6573/14 Badaro, Lebanon.
  • Mouawia H; Nursing Department, Faculty of Health Sciences, Beirut Arab University, Beirut P.O. Box 115020, Lebanon.
  • Fawaz M; Department of Biomedical Sciences, Lebanese International University, Beirut P.O. Box 146404 Mazraa, Lebanon.
  • Hassan H; Department of Cardiology, Rayak University Hospital, Bekaa 1801, Lebanon.
  • Salami A; Faculty of Public Health, Lebanese University, Beirut P.O. Box 6573/14 Badaro, Lebanon.
  • Bazzal AA; Nursing Department, Faculty of Health Sciences, Beirut Arab University, Beirut P.O. Box 115020, Lebanon.
  • Saab HB; Faculty of Public Health, Lebanese University, Beirut P.O. Box 6573/14 Badaro, Lebanon.
  • Al-Wakeel M; Ministry of Health, Beirut P.O. Box 111226, Lebanon.
  • Alsaabi A; Department of Mathematics, Faculty of Sciences, Lebanese University, Nabatieh 1700, Lebanon.
  • Chouman M; Faculty of Public Health, Lebanese University, Beirut P.O. Box 6573/14 Badaro, Lebanon.
  • Moussawi MA; Faculty of Sciences, Lebanese University, Zahle 1801, Lebanon.
  • Ayoub H; Karbala Health Directory, Baghdad 10081, Iraq.
  • Raad A; Department of Biology, Lille University, 59160 Lille, France.
  • Hajjeh O; Faculty of Public Health, Lebanese University, Beirut P.O. Box 6573/14 Badaro, Lebanon.
  • Eid AH; Faculty of Nursing Sciences, Islamic University of Lebanon, Baalbek 1800, Lebanon.
  • Raad H; Department of Cardiology, Rayak University Hospital, Bekaa 1801, Lebanon.
Viruses ; 13(6)2021 05 26.
Article in English | MEDLINE | ID: covidwho-1244149
ABSTRACT

OBJECTIVE:

This study was designed to determine the efficacy of ivermectin, an FDA-approved drug, in producing clinical benefits and decreasing the viral load of SARS-CoV-2 among asymptomatic subjects that tested positive for this virus in Lebanon.

METHODS:

A randomized controlled trial was conducted in 100 asymptomatic Lebanese subjects that have tested positive for SARS-CoV2. Fifty patients received standard preventive treatment, mainly supplements, and the experimental group received a single dose (according to body weight) of ivermectin, in addition to the same supplements the control group received.

RESULTS:

There was no significant difference (p = 0.06) between Ct-values of the two groups before the regimen was started (day zero), indicating that subjects in both groups had similar viral loads. At 72 h after the regimen started, the increase in Ct-values was dramatically higher in the ivermectin than in the control group. In the ivermectin group, Ct increased from 15.13 ± 2.07 (day zero) to 30.14 ± 6.22 (day three; mean ± SD), compared to the control group, where the Ct values increased only from 14.20 ± 2.48 (day zero) to 18.96 ± 3.26 (day three; mean ± SD). Moreover, more subjects in the control group developed clinical symptoms. Three individuals (6%) required hospitalization, compared to the ivermectin group (0%).

CONCLUSION:

Ivermectin appears to be efficacious in providing clinical benefits in a randomized treatment of asymptomatic SARS-CoV-2-positive subjects, effectively resulting in fewer symptoms, lower viral load and reduced hospital admissions. However, larger-scale trials are warranted for this conclusion to be further cemented.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Ivermectin / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: English Year: 2021 Document Type: Article Affiliation country: V13060989

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Ivermectin / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: English Year: 2021 Document Type: Article Affiliation country: V13060989