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Neurological symptoms in hospitalised patients with COVID-19 and their association with in-hospital mortality.
Wnuk, Marcin; Sawczynska, Katarzyna; Kesek, Tomasz; Wrona, Pawel; Chatys-Bogacka, Zaneta; Mazurkiewicz, Iwona; Drabik, Leszek; Jagiella, Jeremiasz; Szaleniec, Joanna; Czepiel, Jacek; Pawlinski, Lukasz; Bien, Artur Igor; Kania, Michal; Fiema, Mateusz; Zieba-Parkitny, Joanna; Hajek, Agnes; Ucieklak, Damian; Wilk, Magdalena; Pospiech, Kamila; Lechowicz, Patrycja; Kasprzycki, Karol; Kopka, Marianna; Hohendorff, Jerzy; Katra, Barbara; Kostrzycka, Malgorzata; Adamczyk, Michalina; Surowiec, Paulina; Rybicka, Monika; Walczewska, Jolanta; Kaminska, Barbara; Pietak, Ewelina; Bryniarski, Pawel; Marona, Monika; Motyl, Maciej; Kepinska-Wnuk, Alicja; Wlodarczyk, Malgorzata; Nowak, Klaudia; Gradek-Kwinta, Elzbieta; Czyzycki, Mateusz; Dwojak, Mateusz; Rzeminska, Agnieszka; Wezyk, Kamil; Kozminski, Wojciech; Pulyk, Agnieszka; Garlicki, Aleksander; Grodzicki, Tomasz; Malecki, Maciej; Slowik, Agnieszka.
  • Wnuk M; Department of Neurology, University Hospital in Krakow, Poland. marcin.a.wnuk@gmail.com.
  • Sawczynska K; Jagiellonian University Medical College, Department of Neurology, Krakow, Poland. marcin.a.wnuk@gmail.com.
  • Kesek T; Jagiellonian University Medical College, Department of Neurology, Krakow, Poland.
  • Wrona P; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland.
  • Chatys-Bogacka Z; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland.
  • Mazurkiewicz I; Jagiellonian University Medical College, Department of Neurology, Krakow, Poland.
  • Drabik L; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland.
  • Jagiella J; Jagiellonian University Medical College, Department of Pharmacology, Krakow, Poland.
  • Szaleniec J; John Paul II Hospital, Krakow, Poland.
  • Czepiel J; Jagiellonian University Medical College, Department of Neurology, Krakow, Poland.
  • Pawlinski L; Jagiellonian University Medical College, Department of Otorhinolaryngology, Krakow, Poland.
  • Bien AI; Department of Otorhinolaryngology, University Hospital in Krakow, Poland.
  • Kania M; Jagiellonian University Medical College, Department of Infectious and Tropical Diseases, Krakow, Poland.
  • Fiema M; Department of Infectious Diseases, University Hospital in Krakow, Poland.
  • Zieba-Parkitny J; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland.
  • Hajek A; Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland.
  • Ucieklak D; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland.
  • Wilk M; Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland.
  • Pospiech K; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland.
  • Lechowicz P; Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland.
  • Kasprzycki K; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland.
  • Kopka M; Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland.
  • Hohendorff J; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland.
  • Katra B; Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland.
  • Kostrzycka M; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland.
  • Adamczyk M; Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland.
  • Surowiec P; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland.
  • Rybicka M; Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland.
  • Walczewska J; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland.
  • Kaminska B; Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland.
  • Pietak E; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland.
  • Bryniarski P; Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland.
  • Marona M; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland.
  • Motyl M; Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland.
  • Kepinska-Wnuk A; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland.
  • Wlodarczyk M; Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland.
  • Nowak K; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland.
  • Gradek-Kwinta E; Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland.
  • Czyzycki M; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland.
  • Dwojak M; Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland.
  • Rzeminska A; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland.
  • Wezyk K; Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland.
  • Kozminski W; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland.
  • Pulyk A; Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland.
  • Garlicki A; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland.
  • Grodzicki T; Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland.
  • Malecki M; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland.
  • Slowik A; Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland.
Neurol Neurochir Pol ; 55(3): 314-321, 2021.
Article in English | MEDLINE | ID: covidwho-1244327
ABSTRACT

OBJECTIVES:

To evaluate the spectrum of neurological symptoms in patients with COVID-19 during the first 14 days of hospitalisation and its association with in-hospital mortality. MATERIAL AND

METHODS:

We included 200 patients with RT-PCR-confirmed COVID-19 admitted to University Hospital in Krakow, Poland. In 164 patients, a detailed questionnaire concerning neurological symptoms and signs was performed prospectively within 14 days of hospitalisation. In the remaining 36 patients, such questionnaires were completed retrospectively based on daily observations in the Department of Neurology.

RESULTS:

During hospitalisation, 169 patients (84.5%) experienced neurological symptoms; the most common were fatigue (62.5%), decreased mood (45.5%), myalgia (43.5%), and muscle weakness (42.5%). Patients who died during hospitalisation compared to the remainder were older (79 [70.5-88.5] vs. 63.5 [51-77] years, p = 0.001), and more often had decreased level of consciousness (50.0% vs. 9.3%, p < 0.001), delirium (33.3% vs. 4.4%, p < 0.001), arterial hypotension (50.0% vs. 19.6%, p = 0.005) or stroke during (18.8% vs. 3.3%, p = 0.026) or before hospitalisation (50.0% vs. 7.1, p < 0.001), whereas those who survived more often suffered from headache (42.1% vs. 0%, p = 0.012) or decreased mood (51.7% vs. 0%, p = 0.003).

CONCLUSIONS:

Most hospitalised patients with COVID-19 experience neurological symptoms. Decreased level of consciousness, delirium, arterial hypotension, and stroke during or before hospitalisation increase the risk of in-hospital mortality.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Country/Region as subject: Europa Language: English Journal: Neurol Neurochir Pol Year: 2021 Document Type: Article Affiliation country: PJNNS.a2021.0039

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Country/Region as subject: Europa Language: English Journal: Neurol Neurochir Pol Year: 2021 Document Type: Article Affiliation country: PJNNS.a2021.0039